健肝颗粒Ⅱ方联合恩替卡韦对HBeAg阳性慢性乙型病毒性肝炎患者外周血T淋巴细胞亚群的影响  

Effect of Jiangan granules Ⅱ combined with entecavir on peripheral blood T cell subsets in HBeAg-positive chronic hepatitis B patients

作　　者：黄国初[1] 黄古叶[1] 顾桥[2] 龙亿芳 潘攀[2] 

机构地区：[1]广西中医药大学第一附属医院,广西南宁530023 [2]广西中医药大学,广西南宁530001

出　　处：《湖南中医杂志》2017年第8期10-13,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：广西壮族自治区卫生适宜技术研究与开发项目(编号:S201307-02)

摘　　要：目的:观察健肝颗粒Ⅱ方联合恩替卡韦对HBe Ag阳性慢性乙型肝炎(CHB)患者外周血T淋巴细胞亚群的影响。方法:将HBe Ag阳性CHB患者300例随机分为对照组和治疗组各150例,治疗组采用健肝颗粒Ⅱ方联合恩替卡韦治疗,对照组单用恩替卡韦治疗。观察比较2组治疗前及治疗12周、24周、52周外周血T淋巴细胞亚群的变化。结果:治疗前2组CD3+、CD4^+、CD8^+T细胞数及CD4^+/CD8^+比值比较,差异无统计学意义(P>0.05);治疗组CD3+、CD4^+、CD8^+T细胞数及CD4^+/CD8^+比值从治疗12周起及其后各时间点较治疗前升高,差异具有统计学意义(P<0.01);对照组CD3+、CD4^+、CD8^+T细胞数及CD4^+/CD8^+比值从治疗24周起及其后各时间点较治疗前升高,差异具有统计学意义(P<0.05);治疗组各指标在各对应时间点的升高幅度均大于对照组,差异具有统计学意义(P<0.05)。结论:健肝颗粒Ⅱ方联合恩替卡韦治疗HBe Ag阳性CHB可提高患者外周血CD3+、CD4^+、CD8^+T细胞计数及CD4^+/CD8^+比值,提高患者细胞免疫功能,其疗效优于单用恩替卡韦。Objective： To observe the effect of Jiangan granules II combined with entecavir on peripheral blood T cell subsets in HBe Ag-positive chronic hepatitis B（ CHB） patients. Methods： Three hundred HBe Ag-positive CHB patients were randomly and equally divided into control group and treatment group. The treatment group received Jiangan granules II combined with entecavir,while the control group received entecavir alone. The two groups were compared in terms of peripheral blood T cell subsets before treatment and at weeks 12,24,and 52 of treatment. Results： Before treatment,there were no significant differences in CD3^＋,CD4^＋,and CD8^＋T cells and CD4^＋/CD8^＋ratio between the two groups（ P〈0. 05）. The treatment group showed significant increases in CD3^＋,CD4^＋,and CD8^＋T cells and CD4^＋/CD8^＋ratio at weeks 12,24,and 52 of treatment（ P〈0. 01）. The control group showed significant increases in CD3^＋,CD4^＋,and CD8^＋T cells and CD4^＋/CD8^＋ratio at weeks 24 and 52 of treatment（ P〈0. 05）. The treatment group had significantly greater increases in the above indices at these time points（ P〈0. 05）. Conclusion： For HBe Ag-positive CHB patients,Jiangan granules II combined with entecavir can increase CD3^＋,CD4^＋,and CD8^＋T cells and CD4^＋/CD8^＋ratio in peripheral blood and improve cellular immune function,and have better efficacy than entecavir alone.

关 键 词：HBEAG阳性慢性乙型肝炎 健肝颗粒Ⅱ方 恩替卡韦 T淋巴细胞亚群 

分 类 号：R259.126.2[医药卫生—中西医结合]