血清中白细胞介素-6和低密度脂蛋白与高血压合并动脉粥样硬化患者颈动脉斑块的关系  

Relationship between interleukin-6 and low density lipoprotein levels in serum and carotid artery plaque in patients with hypertension and atherosclerosis

作　　者：张涛[1] 简斌[1] 谭利国[2] 张涛 

机构地区：[1]湖北医药学院附属人民医院心内科,湖北十堰442000 [2]湖北医药学院附属人民医院心胸大血管外科,湖北十堰4420000

出　　处：《中国卫生检验杂志》2017年第16期2329-2331,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清中IL-6和LDL水平与高血压合并动脉粥样硬化患者颈动脉斑块厚度及斑块类型的关系。方法选择2015年11月-2016年11月本院99例高血压患者作为研究对象,采用酶联免疫吸附法检测患者血清中IL-6水平,全自动生化仪检测患者低密度脂蛋白水平,探讨高血压患者颈动脉病变与患者血清中IL-6和低密度脂蛋白的关系。结果 IL-6高水平组、LDL高水平组患者收缩压、舒张压、脉压均高于对应低水平组患者,差异有统计学意义(P<0.05);IL-6高水平组、LDL高水平组患者斑块内-中膜厚度、斑块面积均高于对应低水平组患者,差异有统计学意义(P<0.05);IL-6高水平组、LDL高水平组患者软斑块、复合斑块发生率均高于低水平组患者,扁平斑块、硬斑块发生率均低于低水平组,差异有统计学意义(P<0.05)。结论 IL-6和LDL水平与患者颈动脉病变程度密切相关,值得临床关注。Objective To investigate the relationship between serum Interleukin-6（ IL-6） and low density lipoprotein（ LDL）levels and carotid plaque thickness and plaque types in patients with hypertension and atherosclerosis. Methods 99 cases in our hospital diagnosed as hypertensive patients from November 2015 to November 2016 were collected as the research objects.The serum level of IL-6 was detected by enzyme-linked immunosorbent assay,and low density lipoprotein level was detected by automatic biochemical analyzer,to explore the relationship between hypertensive patients with carotid artery atherosclerosis and serum IL-6 and low density lipoprotein. Results The systolic blood pressure,diastolic blood pressure and pulse pressure in the groups with high level of IL-6 and LDL were significantly higher than those in the low level groups,intima-media thickness and plaque area were significantly higher than those in the low level groups and the difference was statistically significant（ P〈0. 05）; plaque intimal medial thickness,plaque area in the groups with high level of IL-6 and LDL were significantly higher than those in the low level of groups,and the difference was statistically significant（ P〈0. 05）; patients with soft plaque,plaque incidence rate in the groups with high level of IL-6 and LDL were significantly higher than those in the low level groups; flat plaque and hard plaque incidence were significantly lower than those in the low level group,with the differences statistically significant（ P〈0. 05）. Conclusion The level of IL-6 and LDL is closely related to the degree of carotid artery disease,which is worthy of clinical attention.

关 键 词：白细胞介素-6 低密度脂蛋白 颈动脉 斑块类型 

分 类 号：R543.5[医药卫生—心血管疾病]