泛酸钠对Beagle犬心血管指标的影响  

Effect of Sodium Pantothenate on Cardiovascular in Beagle Dogs

作　　者：张成梅[1] 纪建波[2] 武传涛[1] 宋文延[3] 史艳秋[1] 

机构地区：[1]山东大学实验动物中心,济南250012 [2]山东大学药学院药理学研究所,济南250012 [3]山东大学医学院诊断学研究所,济南250012

出　　处：《实验动物与比较医学》2017年第4期288-291,共4页Laboratory Animal and Comparative Medicine

基　　金：山东省自然科学基金(ZR2011CZ001)

摘　　要：目的观察泛酸钠对Beagle犬心血管指标的影响。方法选取健康Beagle犬16只,雌雄各半,随机分为泛酸钠低剂量(L,0.26mg/kg)、中剂量(M,0.52mg/kg)、高剂量(H,1.04mg/kg)组及生理盐水(NS)对照组,每组4只。静脉给予质量分数3%戊巴比妥钠麻醉,分离一侧颈动脉,插入充满肝素-NS溶液的动脉插管,测定收缩压、舒张压;分离一侧后肢股静脉,按1mL/kg静脉单次给药;将针状电极插入四肢皮下,待动物各项观察指标稳定后,分别记录药前、药后5 min、15min、30min、45min和60min的血压、心率及心电图(ECG)指标。结果 L、M、H三个剂量组与NS组比较,泛酸钠对Beagle犬颈动脉平均动脉压、心率及心电等指标的差异均无统计学意义(P>0.05)。结论泛酸钠对麻醉状态下Beagle犬心血管指标无明显影响。Objective To observe the general influence of sodium pantothenate on the cardiovascular indicators of Beagle dogs. Method Sixteen healthy Beagle dog with half female and male. They were randomly divided into four groups： high, medium and lower dose of sodium pantothenate with 0.26 mg/kg, 0.52 mg/kg, 1.04 mg/kg and normal saline control group （NS）. The dogs were anesthetized with intravenous injection of 3% pentobarbital sodium. The unilateralcarotid artery was dissociated so as to insert the artery cannulae for measuring systolic and diastolic blood pressure. Then unilateralfemoral vein is isolated for a single intravenous injection of 1 mL/kg sodium pantothenate, and electrodes were placed into their limbs to record the indexs of blood pressure, heart rate and electrocardiograph before administration and at different time points after drug administration while each observation index of the Beagle dogs was constant. Result In this experiment, sodium pantothenate did not evidently change the value of blood pressure, heart rate and electrocardiographic in Beagle dogs after intravenous injection （P〉0.05）. Conclusion The sodium pantothenate has no evident effects on the cardiovascular indicators of Beagle dogs.

关 键 词：泛酸钠 心电图指标 血压 心率 BEAGLE犬 

分 类 号：R965[医药卫生—药理学]