假性甲状旁腺功能减退症合并低钾血症临床特点分析  

Pseudohypoparathyroidism and hypokalemia:clinical manifestation analysis

作　　者：张维[1,2] 张梅[1] 王玉成[1] 崔岱[1] 周红文[1] 陈欢欢[1] 袁庆新[1] 李剑波[1] 杨涛[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029 [2]芜湖市第二人民医院内分泌科,安徽芜湖241000

出　　处：《临床荟萃》2017年第9期759-762,共4页Clinical Focus

基　　金：江苏省临床医学科技专项(BL2012026)

摘　　要：目的分析假性甲状旁腺功能减退症(pseudohypoparathyroidism,PHP)合并低钾血症患者的临床特征。方法回顾性分析2006年7月至2016年4月期间在我院住院治疗的13例PHP患者的临床资料。结果 13例患者中男5例,女8例,均无典型Albright遗传性骨营养不良症(Albright’s hereditary osteodystrophy,AHO)躯体畸形,临床表现84.6%的患者有手足抽搐症状,38.5%的患者有四肢乏力、麻木症状;实验室检查6例合并低血钾,10例合并甲状腺功能异常;合并低血钾组病程较长,血钾在3.0~3.5mmol/L,其他临床表现及生化指标与非低血钾组相比差异无统计学意义。结论 PHP患者易合并低钾血症及亚临床甲状腺功能减低。Objective To investigate the clinical characteristics of patients with pseudohypoparathyroidism（PHP）and hypokalemia.Methods The clinical data of 13 patients with PHP in our hospital from July 2006 to April 2016 were analyzed retrospectively.Results None of which had Albright＇s hereditary osteodystrophy（AHD）.Convulsion was observed in 86.4% patients.Myasthenia and numbness of limbs were 38.5%.Hypocalcemia,hyperphospheremia and high level of parathyroid hormone was the main characteristics of laboratory examination.In all 13 cases,hypokalemia rate was 46.2%,10 with abnormal thyroid function.The course of the disease was longer in patients with hypokalemia than controls.There was no significant difference in other clinical manifestation and laboratory examination in patients with or without hypokalemia.There were no typical AHO body deformity.The clinical manifestations of 84.6% patients were tetany symptoms and 38.5% patients had limb weakness and numbness.6 patients were with hypokalemia.10 patients with abnormal thyroid function.The patients with hypokalemia had longer course of disease.The serum potassium was between 3-3.5 mmol/L and other clinical and biochemical indicators and non hypokalemia group had no significant difference.Conclusion PHP patients were susceptible to hypokalemia and subclinical hypothyroidism.

关 键 词：假性甲状旁腺功能减退症 低钾血症 甲状腺功能减退症 

分 类 号：R582.2[医药卫生—内分泌]