老年人低密度脂蛋白胆固醇与死亡率相关的meta分析  

Low-density lipoprotein cholesterol and mortality in the elderly——a meta analysis

作　　者：刘建平[1] 刘燕[1] 吴玉怀[1] 刘建伟[2] 

机构地区：[1]玉溪市人民医院科教科,云南玉溪653100 [2]邯郸市中医院急诊科,河北邯郸056001

出　　处：《临床荟萃》2017年第9期793-797,共5页Clinical Focus

摘　　要：目的系统评价老年人低密度脂蛋白胆固醇(LDL-C)与死亡率之间的关系。方法检索PubMed数据库、Cochrane临床试验数据库、中国知网CNKI、中国生物医学文献数据库CBM和万方数据库,检索时间从建库至2016年12月。筛选队列研究,且含有OR值及95%CI或可通过相关数据计算。结果本次meta分析共纳入5篇文献,共包含50 361例,高LDL-C作为参照组含3篇文章,RR=1.405,95%CI=1.206~1.635,P<0.01,低LDL-C作为参照组含2篇文章,RR=0.552,95%CI=0.506~0.602,P<0.01,不同浓度分析发现,老年人死亡风险随LDL-C浓度升高或降低呈反方向变化。结论老年人LDL-C与死亡率之间存在负相关。Objective To systematically evaluate the association between low-density lipoprotein cholesterol（LDL-C）and mortality.Methods The Pubmed,Cochrane Library,CNKI,CBM and Wangfang databases were searched from building databases to December 2016.The enrollment involved screening cohort studies with ORvalues and 95% CI or the relevant data which can be calculated.Results Five studies with 50 361 participants were finally included.High LDL-C as reference：the pooled RR was 1.405（95% CI =1.206-1.635,P〈0.01）.Low LDL-C as reference：the pooled RR was 0.552（95% CI =0.506-0.602,P〈0.01）.With the change of LDL-C,the risk of mortality became inverse.Conclusion High LDL-C is inversely associated with the all-cause mortality in the elderly.

关 键 词：冠状动脉疾病 低密度脂蛋白胆固醇 因素 统计学 老年人 死亡率 

分 类 号：R541[医药卫生—心血管疾病]