POSS-modified PEG Adhesives for Wound Closure  

作　　者：Ya-zhong Bu Guo-fei Sun Li-cheng Zhang Jian-heng Liu Fei Yang 唐佩福 吴德成 

机构地区：[1]Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry Institute of Chemistry, Chinese Academy of Sciences, Beifing 100190, China [2]University of Chinese Academy of Sciences, Beijing 100049, China [3]Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China

出　　处：《Chinese Journal of Polymer Science》2017年第10期1231-1242,共12页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21674120,81630056,21474115);PLA(No.AWS14C003);“Young Thousand Talents Program”

摘　　要：PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vivo inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.

关 键 词：responsive copolymer glycol polymerization conformation systematically facile assembled hydrogel prepare 

分 类 号：TQ430.1[化学工程]