DNA Hydrogels Formed of Bended DNA Scaffolds and Properties Study  

作　　者：hao-yang jia jie-zhong shi yu shao 刘冬生 

机构地区：[1]Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Journal of Polymer Science》2017年第10期1307-1314,共8页高分子科学（英文版）

基　　金：financially supported by the National Basic Research Program of China(973 program,No.2013CB932803);the National Natural Science Foundation of China(No.21534007);the Beijing Municipal Science&Technology Commission

摘　　要：In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine（C）-rich sequence on both ends. This brick can first assemble to form duplex under p H 8 condition. After adjusting the p H to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.In recent years, DNA supramolecular hydrogels have attracted much attention due to their injectability, biocompatibility, responsiveness and self-healing properties. In this work, we designed a linear DNA brick containing one duplex with two cytosine（C）-rich sequence on both ends. This brick can first assemble to form duplex under p H 8 condition. After adjusting the p H to 5, the C-rich sequence tends to form intermolecular i-motif structure, which joins the linear DNA molecules together to form interlocked cyclic structures and yield the DNA hydrogel. By adjusting the length and bending curvature of the duplex part of the molecule, one can change the basic unit of the hydrogel structure to tune the properties of the DNA hydrogel.

关 键 词：Linear DNA HYDROGEL Bended structures 

分 类 号：O629.74[理学—有机化学] O648.17[理学—化学]