甲氯芬酯联合纳洛酮治疗急性重度酒精中毒疗效性的Meta分析  

A Meta analysis on efficacy of meclofenoxate hydrochloride combined with naloxone in treating acute severe alcoholism

作　　者：葛璐[1] 胡昌龙[1] 胡江鸿[1] 邵秋萍[2] 崔恒熙[2] 王鹏[2] GE Lu HU Changlong HU Jianghong et al(Danyang People ＇ s Hospital of Jiangsu Province, Dan yang 212300, CHINA)

机构地区：[1]丹阳市人民医院,江苏省212300 [2]镇江市第一人民医院

出　　处：《江苏医药》2017年第16期1157-1161,F0003,共6页Jiangsu Medical Journal

摘　　要：目的评价甲氯芬酯联合纳洛酮治疗急性重度酒精中毒的疗效。方法检索PubMed、Embase、the Cochrane Library、中国知网、维普和万方等数据库,收集建库至2017年5月31日的研究甲氯芬酯联合纳洛酮治疗急性重度酒精中毒患者的随机对照试验研究(RCT)资料,采用Rev Man 5.2软件进行Meta分析。结果共纳入7个RCT,496例患者。Meta分析结果显示,应用甲氯芬酯联合纳洛酮治疗急性重度酒精中毒,能有效缩短患者清醒时间[MD=-0.58,95%CI(-0.64^-0.51),P<0.01]及促进患者症状消失[MD=-2.86,95%CI(-4.25^-1.46),P<0.01]。结论应用甲氯芬酯联合纳洛酮治疗急性重度酒精中毒效果优于单用纳洛酮治疗,患者清醒时间及症状消失时间均明显缩短。Objective To evaluate the efficacy of meclofenoxate hydrochloride combined with naloxone in treating acute severe alcoholism.Methods The randomized controlled trials（RCTs）about meclofenoxate hydrochloride combined with naloxone for treating acute severe alcoholism were retrieved in PubMed,EMbase,the Cochrane Library,CNKI,VIP and Wan Fang Data up to May 312017.A Meta analysis was then conducted using RevMan 5.2 software.Results A total of seven RCTs involving 496 patients was finally included.The results of Meta analysis showed that meclofenoxate hydrochloride injection combined with naloxone treatment shortened the time of consciousness awareness[MD=-0.58,95%CI（-0.64,-0.51）,P〈0.01]and the disappearance time of alcoholism symptoms[MD=-2.86,95%CI（-4.25,-1.46）,P〈0.01].Conclusion In the treatment of acute severe alcoholism,combined use of meclofenoxate hydrochloride and naloxone is better than naloxone alone in shortening the time of consciousness awareness and symptoms disappearance.

关 键 词：甲氯芬酯 纳洛酮 酒精中毒 META分析 

分 类 号：R181[医药卫生—流行病学]