再生丝素/羧甲基壳聚糖膜的制备和性能  

Preparation and Properties of Composite Films of Silk Fibroin/Carboxymethyl Chitosan

作　　者：徐水[1,2] 张岩[1,2] 高保东[1,2] 赵诏[1,2] 成国涛[1,2] 朱勇[1,2] XU Shui ZHANG Yan GAO Baodong ZHAO Zhao CHENG Guotao ZHU Yong(College of Biotechnology, Laboratory of Fiber Materials of Southwest University, Chongqing 400715, China Research Center of SilkFiberMaterials Engineering ofChongqing, Chongqing 400715, China)

机构地区：[1]西南大学生物技术学院材料纤维研究室,重庆400715 [2]重庆市蚕丝纤维新材料工程技术研究中心,重庆400715

出　　处：《材料研究学报》2017年第8期612-618,共7页Chinese Journal of Materials Research

基　　金：重庆市蚕丝纤维新材料工程技术中心专项研究(SILKGCZX009);江苏省高校省级重点实验室开放研究课题(KJS1508)~~

摘　　要：用二次冷冻干燥法制备出以戊二醛为交联剂的再生丝素/羧甲基壳聚糖复合材料,研究了不同配比的戊二醛/丝素/羧甲基壳聚糖膜的理化性质。结果表明:这种再生丝素/羧甲基壳聚糖复合材料具有联通的三维多孔结构,孔径分布均匀,丝素与羧甲基壳聚糖之间形成分子间氢键,相容性好;丝素与羧甲基壳聚糖的质量比为1:1,戊二醛的含量为0.20%时共混材料的力学性能最优,且热稳定性较好。植入皮下结果表明,这种复合材料具有良好的生物降解性和生物相容性。Composite films of regenerated silk fibroin/carboxymethyl chitosan were successfully prepared by quadratic freezing-drying method with glutaraldehyde as cross-linking agents, and then of which the physicochemical performance was characterized. The results show that the composite materials show a three-dimensional porous structure with uniform pore distribution; while there exists intermolecular hydrogen bonds between the silk fibroin and the carboxymethyl chitosan, thus they are compatible with each other; Among others, the prepared composite presents the best mechanical property and good thermal stability when the mass ratio of the regenerated silk fibroin to the carboxymethyl chitosan was 1：1and the glutaraldehyde content was 0.20%. The composite material has also good biodegradability and biocompatibility.

关 键 词：复合材料 生物材料 复合膜材料 冷冻干燥 再生丝素 羧甲基壳聚糖 相容性 

分 类 号：TQ341.5[化学工程—化纤工业]