MCV、RDW、LDH及FISH联合检测对骨髓增生异常综合征的诊断价值  

Diagnostic value of joint detection of mean corpuscular volume,red blood cell volume distribution width,lactate dehydrogenase and fluorescence in situ hybridization in myelodysplastic syndrome

作　　者：谢春艳[1] 胡景玉[1] 多亚莉 牟娜[1] 李庆禄[1] 杜红丽[1] 

机构地区：[1]哈励逊国际和平医院检验科,河北衡水053000

出　　处：《海南医学》2017年第15期2484-2485,共2页Hainan Medical Journal

摘　　要：目的探讨平均红细胞体积(MCV)、红细胞体积分布宽度(RDW)、乳酸脱氢酶(LDH)及荧光原位杂交(FISH)联合检测对骨髓增生异常综合征(MDS)的诊断价值。方法选择2013年1月至2015年12月期间哈励逊国际和平医院血液科收治的120例MDS患者为研究对象,同时选择80例健康体检者纳入对照组,比较两组受检者的MCV、RDW、LDH水平,同时对MDS患者进行FISH检测。结果 MDS组患者的MCV、RDW、LDH分别为(102.4±17.2)fL、(18.9±3.7)%、(246.8±59.6)U/L,均明显高于对照组的(87.6±15.3)fL、(13.4±4.2)%、(160.5±38.7)U/L,差异均有统计学意义(P<0.05);MDS患者的FISH检测染色体异常率为60.0%。结论临床上可应用MCV、RDW、LDH对MDS患者进行初步诊断,进一步联合FISH可提高MDS的诊断准确率。Objective To investigate the diagnostic value of joint detection of mean corpuscular volume（MCV）, red blood cell volume distribution width（RDW）, lactate dehydrogenase（LDH） and fluorescence in situ hybridization（FISH） detection in myelodysplastic syndrome（MDS）. Methods During January 2013 to December 2015, 120 MDS patients treated in the Department of Hematology in our hospital were selected as the research objects, and 80 healthy cases were simultaneously selected as the control group. The levels of MCV, RDW, and LDH were detected and compared in the two groups, and the level of FISH was checked in patients with MDS. Results The levels of MCV,RDW and LDH in MDS group were（102.4±17.2） fL,（18.9±3.7）% ,（246.8±59.6） U/L, respectively, which were significantly higher than corresponding（87.6±15.3） fL,（13.4±4.2）% ,（160.5±38.7） U/L in the control group（P0.05）. The abnormal rate of FISH detection in patients MDS was 60.0% . Conclusion MCV, RDW and LDH can be used in the clinical diagnosis of patients with MDS, and further combined with FISH can improve the diagnostic accuracy of MDS.

关 键 词：骨髓增生异常综合征 红细胞 乳酸脱氢酶 荧光原位杂交 诊断 

分 类 号：R442.8[医药卫生—诊断学]