地高辛治疗胎儿快速心律失常的药物动力学模型及其应用  

Pharmacokinetic model of digoxin in the treatment of fetal arrhythmia and its application

作　　者：李冬梅[1] 郭美静 汪琪[2] 

机构地区：[1]哈尔滨理工大学应用科学学院,黑龙江哈尔滨150080 [2]黑龙江省医院儿科,黑龙江哈尔滨150056

出　　处：《高校应用数学学报（A辑）》2017年第3期343-352,共10页Applied Mathematics A Journal of Chinese Universities(Ser.A)

基　　金：黑龙江省自然科学基金(A2016004)

摘　　要：针对孕母及胎儿生长的动态变化规律,建立了通过孕母口服地高辛治疗胎儿快速心律失常的药物动力学模型,根据胎龄变化及临床上地高辛的治疗窗口所反映的血药浓度,设计了合理的用药方案,并运用MATLAB程序进行应用模拟,分析了方案的可行性.In this paper, according to the dynamic change regulation of pregnant mother and fetus growth, a pharmacokinetic model of maternal fetal oral digoxin in the treatment of tachyarrhythmia is established, reasonable regimens on the basis of the gestational age changes and the digoxin therapeutic window of clinical react blood drug concentration are designed, and MATLAB program for simulation, analysising the feasibility of the scheme is used.

关 键 词：胎儿快速心律失常 药物动力学模型 给药剂量 用药方案 

分 类 号：O175[理学—数学]