A crucial role of heme-regulated eIF2α kinase in maintaining cytoskeletal meshwork under an oxygen deficient condition  

作　　者：Guangbo Qu Xiaoyan Wang Sijin Liu 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China [2]University of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Science Bulletin》2017年第15期1045-1047,共3页科学通报（英文版）

基　　金：supported by the State Basic Research Development Program of China (2014CB932000);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB14000000);the National Natural Science Foundation of China (21577165, 21425731, 21077128 and 21637004)

摘　　要：During erythroid differentiation,heme-regulated e IF2α kinase(Hri)is necessary to coordinate translation of globin mRNAs with the availability of heme for the production of large amounts of hemoglobin in red blood cells(RBCs)[1].Our previous study indi-During erythroid differentiation, heme-regulated elF2α kinase （Hri） is necessary to coordinate translation of globin mRNAs with the availability of heme for the production of large amounts of hemoglobin in red blood cells （RBCs） .

关 键 词：血红素 F2Α 细胞骨架 激酶 el 氧气 血红蛋白 mRNA 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]