盐酸麻黄碱滴鼻液3种含量测定方法的比较  

Comparative study on 3 determination methods for Ephedrine Hydrochloride Nasal Drops

作　　者：倪晓霞[1] 王庆芬[1] 刘晓玲[1] 

机构地区：[1]解放军第一七五医院(厦门大学附属东南医院)制剂科,漳州363000

出　　处：《西北药学杂志》2017年第5期600-603,共4页Northwest Pharmaceutical Journal

摘　　要：目的比较盐酸麻黄碱滴鼻液的3种含量测定方法。方法旋光度法(ORD)、紫外分光光度法(UV)和高效液相色谱法(HPLC)。结果 3种方法的平均回收率分别为100.51%(RSD=0.90%),100.85%(RSD=0.53%)和99.72%(RSD=0.90%)。3批盐酸麻黄碱滴鼻液样品的含量测定结果差异无统计学意义。结论 3种方法均适用于盐酸麻黄碱滴鼻液中盐酸麻黄碱的含量测定,其中旋光度法简便、快速,适宜于医院制剂的快速分析。Objective To compare 3 methods for the determination of Ephedrine Hydrochloride Nasal Drops.Methods Polarimetry（ORD）,ultraviolet spectrophotometry analysis（UV）and high performance liquid chromatography（HPLC）were compared.Results The average recoveries were 100.51% with RSD of 0.90% by ORD,100.85% with RSD of 0.53% by UV and 99.72% with RSD of 0.90% by HPLC;the determination results of 3batches for Ephedrine Hydrochloride Nasal Drops showed no significant difference.Conclusion The 3methods were all suitable for the determination of ephedrine hydrochloride,but polarimetry is simple and rapid,which can be used for hospital preparation fast analysis.

关 键 词：盐酸麻黄碱 含量测定 旋光度法 紫外分光光度法 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学]