阿托伐他汀二级预防无症状性脑梗死临床研究  

Clinical study of atorvastatin in the secondary prevention of asymptomatic cerebral infarction

作　　者：钟建华[1] 周桂保[1] 周炳丰[1] 

机构地区：[1]深圳市龙岗中心医院药剂科,深圳518116

出　　处：《西北药学杂志》2017年第5期653-655,共3页Northwest Pharmaceutical Journal

摘　　要：目的分析阿托伐他汀对无症状性脑梗死二级预防作用及对患者脂代谢、颈动脉粥样硬化的影响。方法选取2013年2月~2015年3月的160例无症状性脑梗死患者为研究对象,将其随机均分为对照组和观察组,对照组进行常规的基础干预,观察组则在对照组的基础上加用阿托伐他汀。比较2组患者不同时间的复发率、心血管事件发生率、治疗前及治疗后不同时间的脂代谢指标以及颈动脉粥样硬化的相关指标。结果治疗后3,6及12个月,观察组的复发率及心血管事件发生率均低于对照组,脂代谢指标及颈动脉粥样硬化相关指标也均好于对照组,差异均有统计学意义(P<0.05)。结论阿托伐他汀对无症状性脑梗死二级预防作用较好,对患者脂代谢及颈动脉粥样硬化也有积极的改善作用。Objective To study and analyze the effect of atorvastatin in the secondary prevention of patients with silent cerebral infarction and to study the influence on the lipid metabolism and carotid artery atherosclerosis.Methods 160 patients with silent cerebral infarction from February 2013 to March 2015 were selected as the study objects,and were randomly divided into control group and observation group.The control group were treated with routine basic intervention,while the observation group were treated with atorvastatin on the basic intervention of control group.Then the recurrence rate,incidence of vascular events,lipid metabolism indexes and carotid artery atherosclerosis related indexes before the treatment and at different time after the treatment were compared.Results The recurrence rate and incidence of vascular events of observation group at third,sixth and twentieth month after the treatment were all lower than those of control group,the lipid metabolism indexes and carotid artery atherosclerosis related indexes were all better than those of control group.The differences were statistically significant（P0.05）.Conclusion The effect of atorvastatin in the secondary prevention of patients with silent cerebral infarction is good,and it also has active improvement role for the lipid metabolism and carotid artery atherosclerosis of these patients.

关 键 词：阿托伐他汀 无症状性脑梗死 二级预防作用 脂代谢 颈动脉粥样硬化 

分 类 号：R972[医药卫生—药品]