呼出气一氧化氮浓度评价慢性阻塞性肺疾病严重程度的研究  

Efficacy of Fe NO in severity estimating of chronic obstructive pulmonary disease

作　　者：袁伟锋[1] 胡玉洁[2] 

机构地区：[1]广州军区广州总医院呼吸内科,广东广州510010 [2]中国人民解放军第四五八医院,广东广州510062

出　　处：《临床肺科杂志》2017年第10期1754-1756,共3页Journal of Clinical Pulmonary Medicine

基　　金：广东省医学科学技术研究基金项目(No A2016305)

摘　　要：目的探讨呼出气一氧化氮(Fe NO)检测在协助评价慢性阻塞性肺疾病(慢阻肺)严重程度的临床价值。方法纳入AECOPD患者,分别检测患者就诊与治疗后达稳定期的Fe NO浓度,并以Fe NO浓度阈值25ppb为界,分为正常组与异常组,同时收集患者外周血进行白细胞/中性粒细胞计数、动脉血气分析,并进行BODE评分,分析Fe NO与慢阻肺炎症水平、动脉血气水平、慢阻肺患者活动能力的相关性。结果慢阻肺病情急性加重患者的Fe NO浓度显著高于慢阻肺稳定期患者。在急性加重期患者,Fe NO异常组患者白细胞、中性粒细胞计数均高于Fe NO正常组,Fe NO异常组患者动脉血氧分压低于Fe NO正常组;在稳定期患者,Fe NO正常组患者BODE评分低于Fe NO异常组。结论 AECOPD患者气道内Fe NO浓度增高可能与慢阻肺患者肺组织内炎症反应明显增强有关,并且Fe NO浓度下降与慢阻肺患者病情稳定或趋向好转相关。Objective To evaluate the clinical efficacy of FeNO in severity estimating of COPD. Methods The level of FeNO in AECOPD patients was detected at acute exacerbation and stable phase. All patients were divid-ed into the normal group and the abnormal group according to the concentration of FeNO 25ppb. WBC and neutrophil-ic granulocyte were detected, and arterial blood gas analysis was given BODE score. Results The level of FeNO in acute exacerbation phase was higher than that in stable phase. In AECOPD patients, WBC and neutrophilic granulo-cyte count were higher in the abnormal group than that in the normal group, while arterial partial pressure of oxygen was lower in the abnormal group than that in the normal group. In stationary phase of COPD patients, BODE score was lower in the normal group than that in the abnormal group. Conclusion The increase of FeNO concentration may be related with the inflammation exacerbation in lung of COPD patients. FeNO concentration decrease indicates the improvement of patients condition.

关 键 词：慢性阻塞性肺疾病 呼出气一氧化氮 

分 类 号：R563.9[医药卫生—呼吸系统]