CRP变构及其促炎机制研究进展  

Progress in research of conformation change of C-reactive protein and its pro-inflammatory mechanism

作　　者：姚振宇[1] 武一[1] 吉尚戎[1] YAO ZhenYu WU Yi JI ShangRong

机构地区：[1]兰州大学生命科学学院细胞活动与逆境适应教育部重点实验室,兰州730000

出　　处：《中国科学：生命科学》2017年第8期863-870,共8页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:31470718)资助

摘　　要：天然C-反应蛋白是固有免疫系统中一个进化保守的蛋白,由5个相同亚基通过非共价键形成五聚体结构.C-反应蛋白不仅作为监测炎症的分子标志物,也是炎症发展的直接参与者.C-反应蛋白主要存在两种不同的构型,即五聚体和单体.在炎症微环境,五聚体能够解离形成单体,从而贡献局部炎症反应.为此,本文对C-反应蛋白如何变构以及促炎反应机制的研究进展展开综述.C-reactive protein（CRP） is a highly evolutionarily conserved protein of innate immune system,which consists of five identical subunits that are non-covalently associated as a cyclic pentamer.CRP is not only recognized as a marker,but also directly contributes to the inflammatory process.CRP exists in two major conformationally distinct forms,i.e.native pentameric CRP（pCRP） and modified/monomeric CRP（mCRP）.Dissociation of pCRP into mCRP occurs within the inflammatory microenvironment,which may contribute to development of local inflammatory response.Here we review recent progress in the research of conformational change of CRP,which has been related to its distinct functional properties,and also its pro-inflammatory mechanism.

关 键 词：C-反应蛋白 变构 炎症 

分 类 号：R392[医药卫生—免疫学]