大、小Y染色体携带者精液参数及辅助生殖结局分析  

Association of abnormal length of Y chromosome with semen quality and outcome of assisted reproductive technology in humans

作　　者：李斌业[1] 张永田[1] 曾湘晖[1] 吕金春 

机构地区：[1]青海省人民医院生殖医学中心,青海西宁810007

出　　处：《中华男科学杂志》2017年第9期817-820,共4页National Journal of Andrology

基　　金：青海省基础研究计划项目应用基础研究(2016-ZJ-750)~~

摘　　要：目的:探讨Y染色体长度异常对精液参数以及对ART结局的影响,以期为临床工作提供指导。方法:963例辅助生育患者按Y染色体长度分为正常对照组(n=854),Y>18组(n=24)及Y<22组(n=85),并将Y>18组和Y<22组的精液参数及在ART过程中的胚胎数及优质胚胎数与正常对照组进行比较。用χ~2检验及t检验进行统计学分析。结果:Y>18组中弱精子症患者比例明显低于正常对照组(8.33%vs 31.03%),优质胚胎数较对照组多,差异均有显著性(P<0.05);Y<22组中无精子症比例明显高于正常对照组(16.47%vs 1.87%),在ICSI过程中胚胎数多于正常对照组,差异均有显著性(P<0.05),Y>18和Y<22两组妊娠率与对照组统计学差异均无显著性(P>0.05)。结论:小Y染色体可能对精子发生有影响,而携带大、小Y染色体不会降低ART的妊娠率。因此,对于大、小Y染色体携带不育患者,进行辅助生殖技术可获得和正常核型类似的妊娠结局。Objective ： To investigate the association of the abnormal length of human Y chromosome with semen quality and the out- come of assisted reproductive technology （ART）. Methods： Based on the karyotype, we assigned the patients undergoing ART to a normal control, a long Y chromosome （Y 〉 18）, and a short Y chromosome group （Y 〈22）. We compared the semen parameters and numbers of embryos and high-quality embryos among the three groups of patients and performed statistical analysis of the obtained data using Chi-square distribution and t-test. Results： Compared with the control, the Y 〉 18 group showed a significantly lower incidence rate of asthenozoospermia （31.03% vs 8.33% , P 〈0.05） and a larger number of high-quality embryos （5.46 ± 4.54 vs 7.40 ± 5.49, P 〈 0.05 ）. Both the incidence rate of azoospermia and number of total embryos were remarkably lower in the control than in the Y〈22 group （1.87% vs 16.47% , P 〈0.05; 8.60 ± 7.03 vs 10.00 ± 6.58, P〈0.05）. No statistically s±ignificant differences were found in the pregnancy rate between the Y 〉 18 and Y 〈 22 groups （P 〉 0.05）. Conclusion ： Short Y chromosome may affect soermatoenesis, but the length of Y chromosome does not negatively influence the outcome of ART.

关 键 词：大Y染色体 小Y染色体 精液参数 ART结局 

分 类 号：R698.2[医药卫生—泌尿科学]