精子线粒体DNA与男性不育研究进展  

Sperm mitochondrial DNA and male infertility:An update

作　　者：李刚琴[1] 何映[2] 

机构地区：[1]盱眙县中医院泌尿外科,江苏盱眙211700 [2]江苏省中医院男科,江苏南京210029

出　　处：《中华男科学杂志》2017年第9期848-851,共4页National Journal of Andrology

摘　　要：精子线粒体DNA(mtDNA)与男性生育能力关系密切。mtDNA是裸露的DNA,缺少组蛋白和DNA结合蛋白的保护,易受活性氧(ROS)的攻击,造成氧化损伤,且mtDNA缺少有效的修复系统,ROS引起的精子mtDNA改变将破坏mtDNA编码蛋白的合成,影响线粒体的功能,这可能是男性不育重要遗传学因素。找到引起精子mtDNA损伤的原因及其与男性不育的关系是研究的重点。本文综述了精子mtDNA与男性不育关系的最新研究进展。Sperm mitoehondrial DNA （mtDNA） damage is closely related with male infertility. Lacking for the protection by his- tone and DNA-binding protein, sperm mtDNA is prone to the attack by reactive oxygen species （ROS） and, without an effective repair system of mtDNA, ROS-induced changes in mtDNA may damage the synthesis of mtDNA encoding proteins and affec, t the （kmction of mitochondria, which may be an important genetic factor for male infertility. Related studies should focus on finding the causes of sperm mtDNA damage and its relationship with male infertility. Natl J Androl, 2017, 23 （9） ： 848 -851

关 键 词：精子 线粒体DNA 男性不育 

分 类 号：R698.2[医药卫生—泌尿科学]