甲状腺激素替代治疗对甲状腺功能减退合并OSAHS患者疗效的Meta分析  

The efficacy of thyroid hormone replacement therapy in patients with hypothyroidism and OSAHS:a Meta analysis

作　　者：王苹苹[1] 马磊[1] 吕云辉[2] 相艳[1] 邵党国[1] 孙睿[2] 杨世宏[1] 胡蓉[1] 

机构地区：[1]昆明理工大学信息工程与自动化学院,昆明650500 [2]云南省第一人民医院呼吸科

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第17期1362-1366,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金(No:61163021;No:61702069)

摘　　要：目的:系统评价采用甲状腺激素替代治疗甲状腺功能减退合并OSAHS疾病的疗效。方法:计算机检索Cochrane Library、PubMed、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库、万方资源数据库等数据库并手工检索相关期刊,查找甲状腺激素替代治疗对甲状腺功能减退合并OSAHS患者疗效的病例对照研究,对满足要求的研究进行质量评价,提取相关信息,使用RevMan 5.3和STATA软件进行Meta分析。结果:共纳入7篇病例对照研究。Meta分析结果显示:使用甲状腺激素替代治疗后,甲状腺功能减退合并OSAHS患者的睡眠呼吸暂停低通气指数(AHI)、促甲状腺激素(TSH)、LSaO_2较治疗前有显著改善(P<0.05)。患者的AHI合并效应统计结果为:SMD=3.15,95%CI 4.36~1.94,P<0.000 01,I^2=96%;TSH为:SMD=4.15,95%CI1.15~7.15,P=0.007,I^2=99%;LSaO_2为:SMD=-1.08,95%CI-1.46^-0.70,P<0.000 01,I^2=68%。结论:使用甲状腺激素替代治疗甲状腺功能减退合并OSAHS在显著改善甲状腺功能减退症状的同时,可减轻患者的睡眠呼吸暂停症状。Objective： To systematically evaluate the impact of thyroid hormone replacement in patients with OSAHS and hypothyroidism. Method： The related case-control study of thyroid hormone replacement in patients with OSAHS and hypothyroidism had been searched from Cochrane Library, PubMed, CNKI, Chinese Biomedical Literature Database, Wanfang Resource Database. The case-control study which were in line with the condition need to be evaluated the quality and to be extracted in literature. The RevMan 5.3 and STATA softwares were ap- plied to carry out the Meta-analysis. Result： Seven literatures of case-control study were included. The Meta-analy- sis showed that： After the thyroid hormone replacement, The patient＇s AHI index, TSH index, LSaO2 index were significantly improved （P〈0.05）. The AHI index statistical results of the patients were[SMD= 3. 15,95%CI （4.36-1.94）, P〈0. 00001; I2 =96%], TSH index were[SMD=4.15,95%CI（1.15--7.15）, P=0. 007; I2 = 99%], LSaO2 index were[SMD= - 1.08,95%CI（-1.46--0.70）,P〈0. 000 01, I2 =68%]. Conclusion： The use of thyroid hormone replacement can effectively reduce the patienfs hypothyroidism symptoms and AHI symptoms.

关 键 词：甲状腺激素替代治疗 睡眠呼吸暂停低通气综合征 阻塞性 甲状腺功能减退 META分析 

分 类 号：R563.8[医药卫生—呼吸系统]