某肿瘤专科医院抗肿瘤药致不良反应报告309例分析  

Analysis of 309 Antineoplastics-induced ADR Reports in a Tumor Hospital

作　　者：潘文[1] 李豫[1] 黄天文[1] 雷宇[1] 梁琳琳[2] 

机构地区：[1]广西医科大学附属肿瘤医院临床药学科,南宁530021 [2]广西医科大学药学院,南宁530021

出　　处：《中国药房》2017年第26期3646-3649,共4页China Pharmacy

基　　金：广西壮族自治区卫生厅课题项目(No.Z2014256)

摘　　要：目的:了解抗肿瘤药致药品不良反应(ADR)的特点和发生规律,为临床安全使用抗肿瘤药提供参考。方法:采用回顾性研究方法,对某肿瘤专科医院2015年1-12月收集的309例抗肿瘤药致ADR报告进行统计、分析。结果:309例ADR患者中,女性(58.25%)多于男性(41.75%);40岁以上患者所占比例较高(78.64%);引发ADR的给药途径以静脉滴注为主(94.82%);严重的ADR 225例(72.82%);经停药或治疗后好转的有268例(86.73%)。309例ADR共涉及24种抗肿瘤药物,引发ADR最多的药品依次为多西他赛、顺铂和环磷酰胺;ADR累及器官/系统以造血系统最常见(64.24%),临床表现主要为骨髓抑制。结论:临床应加强抗肿瘤药的ADR监测,及时预防、发现和诊治抗肿瘤药引发的ADR,以减少对患者造成的伤害,保证药物治疗的安全、有效。OBJECTIVE： To investigate the characteristic and regularity of antineoplastics-induced ADR, and to provide refer- ence for safety use of antineoplastics in clinic. METHODS： In retrospective study, 309 cases of antineoplastics-induced ADR col- lected from a special hospital during Jan.-Dec. 2015 were summarized and analyzed statistically. RESULTS： Among 309 ADR cas- es, female （58.25%） was more than male （41.75%）. The patients aged more than 40 years old occupied the highest proportion （78.64 % ）. Main route of administration was intravenous dripping （94.82%）. There were 225 cases of severe ADR （72.82 % ）. To- tal 268 cases were improved after drug withdrawal or treatment （86.73%）. A total of 24 kinds of antineoplastics were involved in 309 ADR cases; most of ADR were induced by docetaxel, followed by cisplatin, cyclophosphamide. Most common organs/system involved in ADR was hemopoietic system （64.24%）, main clinical manifestation was myelosuppression. CONCLUSIONS： It is necessary to strengthen ADR monitoring, prevent, discover and treat antineoplastics-induced ADR timely, in order to reduce the harm to the patients and ensure the safety and effectiveness of drug treatment.

关 键 词：抗肿瘤药 药品不良反应 回顾性分析 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]