迈之灵联合常规药物治疗精索静脉曲张的临床研究  

Clinical Study on Aescuven Forte Combined with Routine Drugs in the Treatment of Varicocele

作　　者：叶纪伟[1] 沈远径[1] 

机构地区：[1]南阳市第二人民医院泌尿外科,河南南阳473000

出　　处：《中国药房》2017年第26期3663-3666,共4页China Pharmacy

摘　　要：目的:探讨迈之灵联合常规药物治疗精索静脉曲张(VC)的临床效果。方法:选择2015年2月-2016年1月我院收治的86例VC患者为研究对象,按照就诊单双号分为对照组和观察组,各43例。对照组患者给予常规药物(枸橼酸氯米芬、左卡尼汀)治疗;观察组患者在对照组基础上加用迈之灵片300 mg,po,bid。两组患者疗程均为3个月。比较两组患者的临床疗效,治疗前后的睾丸动脉血流动力学参数、精浆实验室检查指标、精液质量,以及不良反应发生情况。结果:观察组患者的总有效率为90.70%,明显高于对照组的72.09%,差异有统计学意义(P<0.05)。治疗前,两组患者的上述指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者睾丸动脉向心支的收缩期峰值流速、阻力指数和搏动指数均较治疗前明显降低,α-葡糖苷酶、精浆酸性磷酸酶、精浆果糖含量和前向运动精子活动率、精子总活动率均较治疗前明显升高,精子密度均较治疗前明显增大,且观察组各指标均优于对照组,差异均有统计学意义(P<0.05);但治疗前后两组患者睾丸动脉向心支的舒张末期流速比较,差异均无统计学意义(P>0.05)。两组患者均未见明显不良反应发生。结论:迈之灵联合常规药物有助于改善VC患者睾丸动脉血流状态,调节精浆相关分子含量,提高精液质量,从而提高临床疗效,且安全性较高。OBJECTIVE： To investigate clinical effects of aescuven forte combined with routine drugs in the treatment of vari- cocele （VC）. METHODS： A total of 86 patients with VC selected from our hospital during Feb. 2015-Jan. 2016 were divided into control group and observation group according to odd and even number, with 43 cases in each group. Control group was given rou- tine drug therapy. Observation group was additionally given Aescuven forte tablet 300 mg, po, bid, on the basis of control group. Treatment course of 2 groups lasted for 3 months. Clinical efficacies as well as testicular artery blood flow parameters, seminal plas- ma lab indexes and semen quality were compared between 2 groups. The occurrence of ADR was also compared between 2 groups. RESULTS： Total response rate of observation group was 90.70%, which was significantly higher than 72.09% of control group, with statistical significance （P〈0.05）. Before treatment, there was no statistical significance in above indexes between 2 groups （P〉0.05）. Compared to before treatment, testicular artery peak systolic velocity, resistance index and pulsatility index of 2 groups were decreased significantly after treatment, while plasma a-glucosidase, acid phosphatase, Fructose, sperm activate rate of for- ward movement, total sperm activate rate and sperm density were increased significantly; each index of observation group was bet- ter than that of control group, with statistical significance （P〈0.05） ; there was no statistical significance in end diastolic velocity between 2 groups before and after treatment （P〉0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Aescuven forte combined with routine drug therapy help to improve testicular artery blood flow status of VC patients, regulate the content of semi- nal plasma related molecules and improve semen quality so as to improve clinical efficacy with good safety.

关 键 词：精索静脉曲张 迈之灵 睾丸动脉血流 精浆实验室检查指标 精液质量 

分 类 号：R697.24[医药卫生—泌尿科学]