不同主食成分对糖尿病患者血糖的影响——药食同源主食、小麦纤维主食与普通主食的比较  

Effects of different dietary ingredients on blood glucose in diabetic patients——Comparison among medicine homologous food,wheat fiber and ordinary staple foods

作　　者：何书励[1] 马方[1] 张家瑜[1] 岳燕芬 方京徽[1] 刘鹏举[1] 张殿喜[3] 刘怀成[3] 吴勤勇[3] 张葵[3] 卢双玉[3] 杨国华[3] 

机构地区：[1]中国医学科学院北京协和医院营养科,100730 [2]北京中医医院平谷医院营养科 [3]中国医学科学院北京协和医院检验科,100730

出　　处：《中国糖尿病杂志》2017年第9期773-777,共5页Chinese Journal of Diabetes

基　　金：十二五科技支撑计划(2012BAI35B03)

摘　　要：目的评估添加药食同源成分的特膳主食改善血糖控制的效果。方法选取2014年4月至2015年10月于北京市本研究各中心就诊的糖尿病患者。随机分为3组,进行为期3个月的干预。干预方式为特膳馒头组165例、添加小麦纤维馒头组78例、普通面粉馒头组46例,并给予饮食和运动指导。比较干预前后空腹及标准餐后血糖值、血糖曲线下增加面积(iAUC)和HbA_1c的变化。结果添加药食同源成分的特膳馒头能改善餐后iAUC和HbA_1c,在使用胰岛素或胰岛素促泌剂的患者中,餐后iAUC由403(284,564)mmol·min/L下降至349(258,465)mmol·min/L,HbA_1c由6.9(6.5,8.2)%下降至6.5(6.1,7.5)%,在未使用胰岛素或胰岛素促泌剂的患者中,餐后iAUC由354(245,516)mmol·min/L下降至263(164,364)mmol·min/L(P<0.01),HbA_1c由6.7(6.0,8.0)%下降至6.5(5.7,7.8)%(P<0.01)。普通面粉馒头组的上述指标无变化。结论使用特膳馒头作为主食是一种有效辅助血糖控制的方法。Objective To evaluate the effect of medicinal and edible herbals added with medicine homologous food On blood glucose in patients with diabetes mellitus. Methods Patients with T2DM were enrolled in this study from each center in Beijing from April 2014 to October 2015. All the subjects were randomly divided to 3 groups .. medicinal and edible herbals group （n= 165）, wheat fiber group （n： 78） and ordinary staple food group （n= 46）, and followed up for three months. Dietary and sports guidance were given to all the patients. Fasting blood glucose, post-prandial glucose incremental area under the curve （iAUC） of blood glucose after standard meal, and HbA1c was compared between baseline and endpoint. Results HbA1 c and iAUC were all improved in medicinal and edible herbals group. In patients treated with insulin or Insulin seeretagngues, iAUC declined from 403 （284,564）mmol · min/L to 349（258,465） · min/L（P〈0. 01）,HbAlc declined from 6. 9（6. 5,8. 2）% to 6. 5（6. 1,7. 5）%（P〈 0. 01）. In patients without insulin or Insulin secretagogues treatment,iAUC declined from 354（245,516） mmol· min/L to 263（164,364）mmol · min/L（P〈0.01）, HbA1c declined from 6.7（6.0,8.0）% to 6.5 （5.7,7.8）% （P〈0.01）. The above index did not change in ordinary staple food group. Conclusion Medicinal and edible herbals is effective in blood glucose control.

关 键 词：糖尿病 饮食治疗 

分 类 号：R587.1[医药卫生—内分泌]