儿童青少年注意问题和焦虑／抑郁相关遗传与环境因素影响的双生子研究  

A twin study of genetic and environmental influences on relationship between attention deficit and anxiety/depression in children and adolescents

作　　者：王上上[1,2] 陈天娇[1] 季成叶[1] 

机构地区：[1]北京大学公共卫生学院/北京大学儿童青少年卫生研究所,100191 [2]北京市东城区卫生和计划生育委员会,100007

出　　处：《中华流行病学杂志》2017年第9期1183-1186,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（81001249）

摘　　要：目的探讨遗传和环境因素对儿童青少年注意问题和焦虑／抑郁关联的影响。方法对1062名同性别6～18岁双生子，采用Achenbach儿童行为量表家长用问卷进行调查。使用Mx软件拟合结构方程的单变量模型。构建Cholesky分解模型分析注意问题和焦虑／抑郁中的遗传和环境影响相关。结果注意问题与焦虑／抑郁有遗传相关（r=0．48），共享环境因素相关作用为0．86，非共享环境因素相关作用为0．14。结论遗传因素和共享环境因素对注意问题和焦虑／抑郁的相关起重要作用，非共享环境因素对相关所起作用较小。Objective To understand the genetic and environmental influences on the relationship between attention deficit and anxiety/depression in children and adolescents. Methods A total of 1 062 same-sex twins aged 6-18 years were included in this study. A parent-rated child behavior checklist （CBCL） was used in the assessment. Software Mx was used to fit the univariate model of structural equation. The relationship between attention deficit and anxiety/depression was analyzed through bivariate genetic modeling. Results The genetic factor had influence on the relationship between attention deficit and anxiety/depression （r=0.48）. Shared and non-shared environmental correlation scores of attention deficit and anxiety/depression were 0.86 and 0.14 respectively. Conclusion Common genetic and shared environmental influences can explain the relationship between attention deficit and anxiety/depression in children and adolescents.

关 键 词：注意问题 焦虑/抑郁 遗传和环境 双生子 儿童青少年 

分 类 号：R179[医药卫生—妇幼卫生保健]