薯蓣皂苷元衍生物的合成及其抗肿瘤活性和细胞毒性研究  

Synthesis,Antitumor Activity and Cytotoxicity of Diosgenin Amide Derivatives

作　　者：曾倩倩[1] 孙贝贝[1] 罗卓玛 陈峰[1] 杨学军[1] 杨鸿均[1] 冯豫川[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041

出　　处：《天然产物研究与开发》2017年第9期1455-1463,共9页Natural Product Research and Development

基　　金：西南民族大学研究生创新型科研项目(CX2017SZ015);四川省教育厅研究项目(15ZB0487)

摘　　要：本研究设计并合成了15个新的薯蓣皂苷元衍生物,其结构都通过1H NMR、13C NMR、IR和HR-MS鉴定。所有衍生物采用MTT法对A431和H1975两种细胞株进行体外抗肿瘤活性试验。初步的生物活性测试表明,大多数衍生物都显示出不同程度的抗肿瘤活性。Fifteen novel diosgenin derivatives were designed and synthesized. The structures of all derivatives were con-firmed by 1HNMR,13 C NMR, IR and HR-MS spectra. The antitumor activities of the fifteen derivatives were evaluated a-gainst A431, HI 975 cell lines by MTT assay. The preliminary bioassay test suggested that most of these diosgenin deriva-tives showed different degrees of activities.

关 键 词：薯蓣皂苷元 结构修饰 酰化反应 抗肿瘤活性 酰胺类衍生物 

分 类 号：O629.24[理学—有机化学] R979.19[理学—化学]