输注储存RBC影响循环游离Hb水平和NO消耗的前瞻性研究  

The Prospective Study of Stored RBC Transfusions Effecting Circulating Free Hemoglobin Levels and Nitric Oxide Consumption

作　　者：李秀伟[1] 金薇[1] 胡晓丽[2] 施中凯[3] 冯恩航[3] 蒋蕊[1] 

机构地区：[1]黑龙江省医院输血科,黑龙江哈尔滨150036 [2]黑龙江省医院感染科,黑龙江哈尔滨150036 [3]黑龙江省医院实验诊断部,黑龙江哈尔滨150036

出　　处：《中国卫生标准管理》2017年第18期134-135,共2页China Health Standard Management

基　　金：黑龙江省卫生厅科研课题(名称:输注储存Rbc影响循环游离Hb水平和NO消耗的前瞻性研究编号:2013389)

摘　　要：目的通过研究输注储存红细胞对循环fHb水平和NO消耗的影响,探讨红细胞的储存损伤及不同人群输注储存红细胞后的效果及作用机理。方法此次研究的对象选择2014年7月—2015年6月就医于黑龙江省医院的住院患者30例,将其临床资料进行回顾性分析。结果fHb测定:3组间差别无统计学意义(F0.43,P>0.05);NO测定:3组间差别无统计学意义(F0.998,P>0.05);HP测定:3组间差别无统计学意义(F0.744,P>0.05)。结论 fHb的增高与NO的消耗,理论上可以引起输血不良反应,但是这种反应的发生与否,取决于f Hb、NO与HP的动态平衡状态。Objective To investigate the effect of infusion red blood cells on circulating fHb levels and NO consumption, and to investigate the effect and mechanism of red cell storage in different populations. Methods The subjects of this study were 30 hospitalized patients in Heilongjiang Provincial Hospital from July 2014 to June 2015, and their clinical data were analyzed retrospectively. Results There was no difference between the three groups （F0.43, P 〉 0.05） in fHb; NO measurement there was no difference between the three groups （F0.998, P 〉 0.05）; HP measurement： there was no difference between the three groups （F0.744, P 〉 0.05）. Conclusion The increase of fHb and the consumption of NO can theoretically cause adverse reactions of blood transfusion, but the occurrence of this reaction depends on the dynamic equilibrium state of fHb, NO and HP.

关 键 词：输注 储存红细胞 游离Hb NO HP 

分 类 号：R331[医药卫生—人体生理学]