左西孟旦与米力农注射液治疗老年失代偿性心力衰竭临床疗效的对比研究  

Comparative Study for Clinical Effect in Treating Elderly Patients with Decompensated Heart Failure between Levosimendan and Milrinone Injection

作　　者：胡学松 冷利华[2] 

机构地区：[1]海军安庆医院医务处,安徽省安庆市246001 [2]海军安庆医院心血管内科,安徽省安庆市246001

出　　处：《实用心脑肺血管病杂志》2017年第8期78-81,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：安徽省教育厅自然科学基金重点项目(KJ2015B4578)

摘　　要：目的比较左西孟旦与米力农注射液治疗老年失代偿性心力衰竭的临床疗效。方法选取2014年2月—2016年12月海军安庆医院心血管内科收治的老年失代偿性心力衰竭患者90例,采用随机数字表法分为对照组和观察组,每组45例。在常规治疗基础上,对照组患者给予米力农注射液治疗,观察组患者给予左西孟旦治疗。比较两组患者临床疗效,治疗前、治疗后7 d心功能指标[脑钠肽(BNP)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、心脏指数(CI)、心率(HR)]及呼吸频率、呼吸困难症状评分,并观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者血清BNP水平、LVEF、LVEDD、CI、HR比较,差异无统计学意义(P>0.05);治疗后7 d观察组患者血清BNP水平、LVEDD、HR低于对照组,LVEF、CI高于对照组(P<0.05)。治疗前两组患者呼吸频率、呼吸困难症状评分比较,差异无统计学意义(P>0.05);治疗后7d观察组患者呼吸频率、呼吸困难症状评分低于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论左西孟旦治疗老年失代偿性心力衰竭的临床疗效优于米力农注射液,可更有效地改善患者呼吸困难症状及心功能,且安全性较高。Objective To compare the clinical effect in treating elderly patients with decompensated heart failure between levosimendan and milrinone injection. Methods From February 2014 to December 2016,a total of 90 elderly patients with decompensated heart failure were selected in the Department of Cardiovascular Medicine,Naval Anqing Hospital,and they were divided into control group and observation group according to random number table,each of 45 cases. Based on conventional treatment, patients of control group received milrinone injection, while patients of observation group received levosimendan. Clinical effect,index of cardiac function（ including BNP,LVEF,LVEDD,CI and HR）,respiratory rate and dyspnea symptom score before treatment and after 7 days of treatment were compared between the two groups,and incidence of adverse reactions was observed during the treatment. Results Clinical effect of observation group was statistically significantly better than that of control group（ P〈0. 05）. No statistically significant differences of serum BNP level,LVEF,LVEDD,CI or HR was found between the two groups before treatment（ P〉0. 05）; after 7 days of treatment,serum BNP level,LVEDD and HR of observation group were statistically significantly lower than those of control group,while LVEF and CI of observation group were statistically significantly higher than those of control group（ P〈0. 05）. No statistically significant differences of respiratory rate or dyspnea symptom score was found between the two groups before treatment（ P〉0. 05）, while respiratory rate and dyspnea symptom score of observation group were statistically significantly lower than those of control group after treatment（ P〈0. 05）. No statistically significant differences of incidence of adverse reactions was found between the two groups during the treatment（ P〉0. 05）. Conclusion Levosimendan has better clinical than milrinone injection in treating elderly patients with decompensated heart failure,can more effectively reliv

关 键 词：心力衰竭 老年人(65-79) 左西孟旦 米力农注射液 疗效比较研究 

分 类 号：R544.1[医药卫生—心血管疾病]