基于Mn掺杂ZnS量子点温室磷光检测左氧氟沙星  

Detection of Levofloxacin by room temperature phosphorescence method based on Mn doped Zn S quantum dots

作　　者：安昭琦 栗东霞[1] 闫桂琴[1] 

机构地区：[1]山西师范大学生命科学学院,山西临汾041000

出　　处：《应用化工》2017年第9期1839-1843,共5页Applied Chemical Industry

基　　金：国家自然科学基金项目(31272258);国家教育部博士点联合基金项目(20111404110002);山西省重点化学优势学科建设项目(912019)

摘　　要：以3-巯基丙酸为稳定剂,采用水相合成法制备Mn掺杂Zn S量子点,由于左氧氟沙星(LVFX)的3-羰基与Mn掺杂Zn S量子点表面的二价金属离子形成配合物,使得Mn掺杂Zn S量子点发生温室磷光猝灭效应,从而构建了一种快速、灵敏检测人体体液中LVFX的新方法。在最佳条件下(p H 7.4,反应时间10 min),其线性关系△RTP=27.56c(LVFX)+52.002(R=0.995),线性范围0.5~100μmol/L,检出限0.35μmol/L,加标回收率96.2%~104.6%,可用于LVFX注射液与人体尿液中LVFX的快速测定。By taking 3-mercaptopropionic acid( MPA) as the stabilizer and preparing Mn doped ZnS quantum dots( QDs) by means of water phase synthesis method,room temperature phosphorescence quenching effect was happened to the Mn doped ZnS quantum dots because of the coordination complex formulated by bivalent metal ions on the surface of 3-carbonyl in Levofloxacin( LVFX) and Mn doped ZnS quantum dots,thus,a new rapid and sensitive method to detect LVFX in human body fluid was developed. Under optimum conditions( pH 7. 4,reaction time 10 min),with a linear relationship of △RTP =27. 56c( LVFX) + 52. 002( R = 0. 995),linear scope of 0. 5 ~ 100 μmol/L,and the detection limit and standard addition recovery of 0. 35 μmol/L and 96. 2% ~ 104. 6%,respectively,this method can be used for rapid detection of LVFX injection and LVFX in human urine.

关 键 词：Mn掺杂ZnS量子点 温室磷光 左氧氟沙星 

分 类 号：TQ034[化学工程] TQ420.711