高效抗逆转录病毒疗法治疗艾滋病患者的疗效与安全性  

Clinical trial and safety of highly active antiretroviral therapy in the treatment of human immunodeficiency virus patients

作　　者：陈素梅[1] 林永年[1] 何秀华[1] 刘江福[1] 郭如意[1] 高易鹏 

机构地区：[1]福建医科大学附属泉州第一医院感染科,福建泉州362000 [2]泉州市传染病院,福建泉州362000

出　　处：《中国临床药理学杂志》2017年第17期1618-1620,共3页The Chinese Journal of Clinical Pharmacology

基　　金：泉州市科技计划基金资助项目(2013Z67)

摘　　要：目的研究高效抗逆转录病毒疗法(HAART)在艾滋病(HIV)患者中的应用。方法入选2013年6月至2015年1月本院收治的艾滋病患者60例为研究对象,对所有患者均给予高效抗逆转录病毒疗法,采取联合治疗:拉米夫定0.3 g qd,齐多夫定0.3 g bid,依非韦伦600 mg qn。治疗后3,6,12个月,比较患者的CD4^+T淋巴细胞计数和HIV病毒载量变化,分析患者的临床疗效和药物不良反应。结果治疗12个月后患者的有效率为93.33%(56/60例)。CD4^+T淋巴细胞计数和病毒载量:与治疗前的(104.74±9.58)pcs·μL^(-1)、(7.76±0.42)g·copies·m L^(-1)比较,治疗3个月后分别为(144.64±6.47)pcs·μL^(-1)、(4.80±0.20)g·copies·m L^(-1),差异均有统计学意义(均P<0.05)。有7例患者发生骨髓抑制,5例发生肝毒性(在治疗后1,2个月出现),3例出现Ⅱ级末梢神经炎(在治疗后3,4,6个月出现)。结论 HAART疗法对HIV患者进行治疗,免疫学和病毒学效果良好。Objective To study application of highly active antiretroviral therapy （HAART） in the treatment of human immunodeficieney virus （ AIDS ） patients. Methods From June 2013 to January 2015, 60 cases of AIDS patients in our hospital were researched, both were given HAART, all patients were taken lamivudine 0. 3 g qd, zidovudine 0. 3 g bid, efavirenz tablets 600 rag qn, 1 time/day. Before and after treatment of 3 months, 6 months, 12 months, patients with CD4 - ＋ T lymphocyte counts and HIV viral load changes were determined. The patient＇s clinical curative effect and adverse drugs reaction were analyzed. Results After 12 months treatment, the total effective rate was 93.33% （56/60 cases）. After 3 months treatment, among CD4 - ＋ T lymphocyte count was significantly increased than before treatment [ （144.64 ±6.47） vs （ 104. 74 ± 9.58 ） pcs ·μL-（-1）, viral load was significantly reduced than before treatment [ （ 4. 80 ± 0. 20 ） vs （7.76±0.42） g · copies · mL-1）, the difference had statistical significance （all P 〈 0. 05 ）. There were 7 patients bone marrow suppression, 5 cases had liver toxicity （occured in 1, 2 months after treatment） ; 3 cases with II and peripheral neuritis （occured in 3, 4, and 6 months after treatment）. Conclusion HIV patients with HAARTtherapy has better effect of immunology and virology.

关 键 词：高效抗逆转录病毒疗法 艾滋病 CD4+T淋巴细胞计数 病毒载量 

分 类 号：R978.7[医药卫生—药品]