破骨细胞功能研究进展  

Research progress of osteoclast function

作　　者：顾建红[1,2] 孔琦[1] 王东[1] 袁燕[1,2] 卞建春 刘学忠[1,2] 刘宗平[1,2] 

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009

出　　处：《中国兽医学报》2017年第9期1797-1801,共5页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(31302154);江苏省高校自然科学基金资助项目(13KJB230002);教育部博士点基金新教师类资助项目(20133250120002);江苏高校优势学科建设工程资助项目

摘　　要：破骨细胞一直被认为是一种仅在骨重建中发挥骨吸收作用的细胞,然而,近几年这一观点已彻底改变。这种多核细胞在体内具有复杂的生物学功能。除了能够吸收钙化的骨基质以外,破骨细胞在骨形成、骨组织血管形成、关节软骨生理病理过程、免疫和代谢调节中均发挥着重要作用。The osteoclast has been considered as a cell with the exelusive function of bone remodel- ling. However, this concept has been changed drastically according to the advances in the last few years. These multinuclear cells play multifunctional role in vivo. In addition to its ability of reab- sorbing the calcified bone matrix, the osteoclast plays important role in bone formation, angiogene- sis, physiology and pathology of cartilage, immunological regulation and metabolic modulation.

关 键 词：破骨细胞 骨质疏松 血管形成 免疫 代谢 

分 类 号：S856.5[农业科学—临床兽医学] S852.1[农业科学—兽医学]