飞行员CX-37基因多态性与冠状动脉硬化的关系  

Correlation Study on Pilots' Connexin-37 Gene Polymorphism and Coronary Atherosclerosis

作　　者：牟宗阳 殷雪娇 刘兴德[1] 罗惠兰[3] 

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]锦州医科大学,辽宁锦州121001 [3]中国人民解放军空军总医院,北京100036

出　　处：《贵州医科大学学报》2017年第8期872-875,892,共5页Journal of Guizhou Medical University

基　　金：全军"十二五"重点基金资助项目(BWS11J054)

摘　　要：目的:研究飞行员冠状动脉粥样硬化(AS)患者血清间隙连接蛋白37(CX-37)水平及CX-37基因-1019C>T位点的基因多态性与AS的关系。方法:选取确诊有AS的飞行员及普通人,健康飞行员和普通健康体检者,测定血清CX-37水平,比较4组受检者CX-37基因-1019C>T位点的基因型分布和等位基因的频率。结果:飞行员AS组及普通人AS组血清CX-37水平明显高于飞行员正常组及普通人正常组(P<0.05),但是普通人AS组与飞行员AS组CX-37水平比较,差异无统计学意义(P>0.05);4组CX-37基因-1019C>T位点CC、CT、TT基因型分布及等位基因频率比较,差异无统计学意义(P>0.05)。结论:飞行员的工作性质不影响血清CX-37的表达水平,CX-37基因-1019C>T位点基因多态性与AS发病无关。Objective： To investigate the relationship between pilots＇ coronary atherosclerosis （AS）, serum CX-37 level and CX-37 gene-1019C 〉 T site polymorphism. Methods： Selecting atherosclerosis pilots, healthy people, healthy pilots, ordinary healthy subjects, testing their serum CX-37, and com- paring CX-37 gene-1019C 〉 T site geno-distribution and allele frequency of four groups. Results ： The serum CX-37 level in AS pilot group and in healthy people AS group were significantly higher than those in pilot group and normal group （P 〈 0.05 ） ; comparing CX-37 level of healthy people AS group and AS pilot group, differences were not statistically significant （P 〉 0. 05 ） ; comparing CX-37 gene- 1019C 〉 T site CC, CT and T-F geno-distribution and allele frequency, differences were not statistically significant （ P 〉 0.05 ）. Conclusion ： The work itself of pilot has no effect on CX-37 expression, CX-37 gene-1019C 〉 T site polymorphism has no significant effect on coronary atherosclerosis.

关 键 词：飞行员 缝隙连接蛋白质类 多态性 单核苷酸 冠状动脉疾病 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]