N-溴代丁二酰亚胺催化水杨醛与麦氏酸反应合成香豆素-3-羧酸  

N-Bromosuccinimide Mediated the Reaction of 2-Hydroxyaryl Aldehydes with Meldrum's Acid for Synthesis of Coumarin-3-carboxylic Acids

作　　者：阮鸿力 张婧圆 孙赛[1] 杨颖[1] 朱小磊 吕成伟[1] 

机构地区：[1]辽宁师范大学化学化工学院,大连116029 [2]鞍山市教师进修学校,鞍山14000

出　　处：《有机化学》2017年第8期2139-2144,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21403100);辽宁省博士启动基金(No.20141100)资助项目~~

摘　　要：室温条件下、水和乙醇的混合液中,N-溴代丁二酰亚胺(NBS)促进2-羟基苯甲醛与麦氏酸连续发生Knoevenagel缩合反应和分子内环化反应,高产率地合成了一系列的香豆素-3-羧酸.该方法扩展了可用于合成香豆素-3-羧酸的催化剂的种类,同时还具有催化剂廉价易得、反应条件清洁环保、底物适用性广、后处理简单和产物易于纯化等优点.A N-bromosuccinimide（NBS） promoted procedure for the synthesis of coumarin-3-carboxylic acids via Knoevenagel-intramolecular cyclization cascade reaction of Meldrum＇s acid with various 2-hydroxyarylaldehydes has been developed. Using the mixture of water and ethanol as solvent, employing inexpensive NBS as the catalyst, and reacted at room temperature are found to highly applicable to get a satisfactory outcome. This approach expands the method for the preparation of coumarin-3-carboxylic acids and also provides other features such as mild reaction conditions, tolerant the substrates with diverse functional groups, simple workup procedure and easy isolation.

关 键 词：N-溴代丁二酰亚胺 香豆素-3-羧酸 合成方法 室温 绿色化学 

分 类 号：O626[理学—有机化学] O643.36[理学—化学]