无金属参与的α-羰基二硫缩烯酮的硫甲基化反应  

Metal-Free Thiomethylation of α-Oxoketene Dithioacetals

作　　者：张海峰[1] 鲍汉扬 徐峥[1] 刘运奎[1] 

机构地区：[1]浙江工业大学化学工程学院绿色化学与技术国家重点实验室培育基地,杭州310014

出　　处：《有机化学》2017年第8期2153-2158,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21172197;21372201);浙江工业大学"省重中之重一级学科"开放基金资助项目~~

摘　　要：以二甲基亚砜(DMSO)为硫甲基来源,以NH_4I为促进剂,实现了α-羰基二硫缩烯酮的硫甲基化反应,合成了硫甲基取代的α-羰基二硫缩烯酮类化合物.通过研究溶剂、温度、反应时间、促进剂及其用量等因素对反应的影响,获得了最优的反应条件.该反应具有原料简单易得、操作简便、底物普适性好和无金属参与等优点.With dimethyl sulfoxide（DMSO） as a source of thiomethyl group and NH_4I as a promotor, the thiomethylation of α-oxoketene dithioacetals has been achieved to afford thiomethylated α-oxoketene dithioacetals in moderate to good yields. The optimized reaction conditions were established through systematic investigations of solvents, temperature, time, promotors and their dosages in the reaction. The present reaction has advantages of easy availability of starting materials, simple operation, good compatibility of substrates, and metal-free reaction conditions.

关 键 词：二甲亚砜 Α-羰基二硫缩烯酮 硫甲基化 无金属参与 

分 类 号：O621.25[理学—有机化学]