羟考酮复合丙泊酚麻醉用于结肠镜检查的效果观察  

Effect Observation of Oxycodone Combined with Propofol in Colonoscopy

作　　者：刘宇芳[1] 黄晓晨[2] 

机构地区：[1]解放军101医院麻醉科,江苏无锡214041 [2]苏州市立医院北区麻醉科,江苏苏州215008

出　　处：《中国血液流变学杂志》2017年第1期62-65,共4页Chinese Journal of Hemorheology

摘　　要：目的 探讨不同剂量羟考酮复合丙泊酚用于肠镜检查的临床疗效.方法 将100例门诊行无痛肠镜检查的患者随机分为4组（n=25）：0.05 mg/kg羟考酮复合丙泊酚麻醉为A组,0.1 mg/kg羟考酮复合丙泊酚麻醉为B组,0.2 mg/kg羟考酮复合丙泊酚麻醉为C组,生理盐水复合丙泊酚麻醉为D组.记录患者入室时（T1）,给药5 min后（T2）,过脾区（T3）,苏醒时（T4）患者心率、血压、血氧饱和度的变化,同时记录患者丙泊酚用量、术后苏醒时间以及不良反应的发生情况.结果与D组相比,B组、C组患者体动、丙泊酚用量明显降低,过脾区生命体征更平稳.但C组有较多患者出现呼吸抑制,且苏醒时间明显延长（P〈0.05）;A组与D组差异无统计学意义（P〉0.05）.结论 0.1 mg/kg羟考酮复合丙泊酚用于无痛内镜检查既达到良好的镇静镇痛效果,又可减少围术期不良反应的发生,患者苏醒较快,是一种安全有效的方法.Objective To observe the clinical effects of different doses of oxycodone combined with propofol in painless endoscopy. Methods 100 cases of outpatients with painless colonoscopy were randomly divided into 4 groups （n=25）： patients anesthetized with 0.05 mg/kg of oxycodone combined with propofol as group A, patients anesthetized with 0.1 mg/kg of oxycodone combined with propofol as group B, patients anesthetized with 0.2 mg/kg of oxycodone combined with propofol as group C, and patients with physiological saline combined with propofol anesthesia as group D. Changes of heart rate, blood pressure, and blood oxygen saturation of patients were recorded at entering room （T1）, 5 min after medication （T2）, passing the spleen area （T3） and waking （T4）, while the dosage of propofol, postoperative recovery time and adverse reactions were also recorded. Results Compared with group D, the dosage of propofol and patient＆#39;s body movement were obviously decreased in group B and group C, the vital signs are more stable when passing the spleen area; but more patients of group C appeared respiratory depression, with obviously prolonged recovery time （P〈0.05）; and there were no statistically significant differences between group A and group D （P〉0.05）. Conclusion 0.1mg/kg oxycodone combined with propofol is a safe and effective method in painless endoscopy. It can achieve good sedation and analgesic effect while reducing the perioperative incidence of adverse reactions and in addition, the patient revives faster.

关 键 词：羟考酮 肠镜 丙泊酚 体动 苏醒延迟 

分 类 号：R614[医药卫生—麻醉学]