鲍曼不动杆菌耐药性与抗菌药物使用强度的相关性分析  

Analysis of correlation between antibiotics use density and acinetobacter baumannii drug resistance

作　　者：旷南岳[1] 李璇[1] 李文军[1] 

机构地区：[1]新疆生产建设兵团医院药学部,新疆乌鲁木齐830001

出　　处：《临床药物治疗杂志》2017年第5期27-29,共3页Clinical Medication Journal

基　　金：新疆兵团科技计划项目(No:2015AB034)

摘　　要：目的:分析新疆生产建设兵团医院抗菌药物使用强度(AUD)与鲍曼不动杆菌耐药性变化的相关性,为临床合理用药提供参考依据。方法:回顾性统计2011—2016年该院鲍曼不动杆菌耐药性和抗菌药物的使用情况,采用Pearson和Spearman相关法对AUD与鲍曼不动杆菌耐药性进行相关性分析。结果:2011—2016年共分离出病原菌14 972株,其中鲍曼不动杆菌1 642株,检出率为10.97%;哌拉西林/他唑巴坦及亚胺培南的使用强度与鲍曼不动杆菌的耐药率呈正相关(P≤0.05),其他药物的耐药率与AUD无显著相关性。结论:哌拉西林他唑巴坦及亚胺培南的使用,是导致鲍曼不动杆菌耐药的重要原因之一。Objective： To analyze the correlation between antibiotics use density （AUD） and acinetobacter baumannii （A. baumannii） drug resistance in our hospital so as to provide reference for rational drug use in clinic. Methods： A retrospective statistics was made on the A. baumannii drug resistance and antibiotic use in our hospital from 2011 to 2016. Pearson and Spearman correlation tests were performed to analyze the correlation between AUD and A. baumannii drug resistance. Results： A total of 14 972 strains of pathogenic bacteria were isolated during 2011-2016, there of, 1 642 strains were A. baumannii. The detection rate was 10.97%. The use densities of piperacillin- tazobactam and imipenem were positively correlated with the A. baumannii drug resistance rate （P ≤ 0.05）, while the resistance rates of other drugs were not clearly correlated to AUD. Conclusion： The use of piperacillin-tazobactam and imipenem is one of the key factors resulting in drug resistance ofA. baumannii.

关 键 词：鲍曼不动杆菌 抗菌药物 耐药性 使用强度 相关性 

分 类 号：R978.5[医药卫生—药品]