葛根素在肥胖型多囊卵巢综合征治疗过程中的抗氧化应激作用  

Anti-oxidative stress effect of puerarin in the course of the treatment for obese polycystic ovary syndrome

作　　者：李文静[1] 胡红波[1] 朱少芳[1] 刘静[1] 林炳根 李泛湘 

机构地区：[1]韶关市粤北人民医院妇科,广东韶关512026

出　　处：《中国妇幼保健》2017年第17期4111-4116,共6页Maternal and Child Health Care of China

基　　金：广东省科技计划项目(2013B021800092);广东省中医药局建设中医药强省科研立项课题(20151108)

摘　　要：目的研究葛根素在肥胖型多囊卵巢综合征(PCOS)治疗过程中的抗氧化应激作用。方法收集30例肥胖型PCOS患者,随机分为肥胖型治疗组15例和肥胖型对照组15例,收集15例瘦型PCOS患者设为瘦型治疗组。肥胖型对照组只给予达英35和二甲双胍治疗,肥胖型PCOS治疗组和瘦型治疗组除以上治疗外,还给予葛根素口服,疗程均为3个月。收集治疗前后3组的数据,系统评价葛根素对3组PCOS患者在改善临床症状、激素水平、生化指标和抗氧化能力等方面的有效性和安全性。结果葛根素可改善肥胖型PCOS患者的闭经情况,且体质量指数(BMI)纠正比瘦型者好;可降低肥胖型PCOS患者的游离雄激素、胰岛素抵抗;可以升高肥胖型PCOS患者的高密度脂蛋白胆固醇(HDL-C),降低瘦型者的甘油三酯(TG);可加强肥胖型PCOS患者中酶类谷胱甘肽过氧化物酶(GPX)、非酶类维生素E(Vit E)的抗氧化能力,而对于瘦型PCOS患者服用葛根素的抗氧化能力纠正更强。无论肥瘦,葛根素均可提高Vit E的抗氧化能力,但不能改变催乳素(PRL)、雌酮(E1)/雌二醇(E2)>1。结论葛根素治疗PCOS患者作用靶点在于对抗高雄激素、胰岛素抵抗和脂质代谢异常,并提高抗氧化能力,前3点肥胖者明显,抗氧化则瘦型者明显。Objective To research the anti-oxidative stress effect of puerarin in the course of the treatment for obese polycystic ovary syndrome （PCOS）.Methods Thirty obese PCOS patients were collected and randomly divided into obesity treatment group （15 patients） and obesity control group （15 patients）.Fifteen thin PCOS patients were collected as thin treatment group.The patients in obesity control group were treated by Diane-35 and metformin;the patients in obesity treatment group and thin treatment group were treated by Diane-35 and metformin combined with oral administration of puerarin.The patients in the three groups were treated for three months.The data before and after treatment in the three groups were collected.The effectiveness and safety of puerarin in improving clinical symptoms,hormones levels,biochemical parameters,and antioxidant capacity in the three groups were systematically evaluated.Results Puerarin improves amenorrhoea of patients with obese PCOS,and improvement of body mass index （BMI） was better than thin PCOS patients.Puerarin reduced free androgen level and insulin resistance of patients with obese PCOS.Puerarin increased high-density lipoprotein cholesterol （HDL-C） level of patients with obese PCOS,and it reduced the level of triglyceride of thin PCOS patients.Puerarin enhanced the antioxidant capacity of glutathione peroxidase （GPX） and non-enzyme vitamin E （Vit E） in patients with obese PCOS,and the antioxidant capacity was improved strongly in thin PCOS patients after puerarin treatment.Puerarin improved the antioxidant capacity of VE for both obese and thin PCOS patients,but it couldn＆#39;t change prolactin （PRL） level and estrone （E1） / estradiol （E2） 〉 1.Conclusion Puerarin treatment for PCOS is aimed at antagonizing high androgen,insulin resistance,and abnormal lipid metabolism,and increasing the antioxidant capacity.The first three points are obvious among obese PCOS patients,while antioxidant capacity is obvious among thin PCOS patients.

关 键 词：葛根素 多囊卵巢综合征 肥胖型 

分 类 号：R711.75[医药卫生—妇产科学]