匹伐他汀与阿托伐他汀治疗高胆固醇血症的疗效比较  

Efficacy comparison of pitavastatin and atorvastatin in the treatment of hypercholesterolemia

作　　者：郑继标 陈丽莲[1] 蔡静月[1] 梁国钦[2] 彭俊[2] 吴永娟[2] 

机构地区：[1]湛江中心人民医院药剂科,624037 [2]湛江中心人民医院心内科,624037

出　　处：《中国实用医药》2017年第24期89-91,共3页China Practical Medicine

摘　　要：目的比较匹伐他汀与阿托伐他汀治疗高胆固醇血症的疗效。方法 126例高胆固醇血症患者,随机分为对照组及观察组,各63例。对照组采用阿托伐他汀钙片进行治疗,观察组采用匹伐他汀钙片进行治疗。对两组患者的治疗效果进行对比。结果治疗前,两组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇均明显下降,高密度脂蛋白胆固醇水平明显升高(P<0.05),但组间比较差异均无统计学意义(P>0.05)。两组患者均未出现严重的不良反应。结论匹伐他汀与阿托伐他汀在治疗高胆固醇血症方面疗效相当,基本安全,值得临床推广使用。Objective To compare the efficacy of pitavastatin and atorvastatin in the treatment of hypercholesterolemia. Methods A total of 126 hypercholesterolemia patients were randomly divided into control group and observation group, with 63 cases in each group. The control group was treated with atorvastatin calcium tablets, and the observation group was treated with pitavastatin calcium tablets. The treatment effect in two groups was compared. Results Before treatment, both groups had no statistically significant difference in total cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels （P〉0.05）. After treatment, both groups had obviously lower total cholesterol, triglyceride, low-density lipoprotein cholesterol and obviously higher high-density lipoprotein cholesterol level （P〈0.05）, but their difference had no statistical significance （P〉0.05）. There were no serious adverse reactions in two groups. Conclusion Pitavastatin and atorvastatin shows equal efficacy in treating hypercholesterolemia, and they are basically safe. So it is worthy of clinical promotion and use.

关 键 词：匹伐他汀 阿托伐他汀 高胆固醇血症 疗效 

分 类 号：R589.2[医药卫生—内分泌]