银屑病与慢性炎症性肠病的相关性研究进展  

Correlations between psoriasis and chronic inflammatory bowel disease

作　　者：邓维 于瑞星[2] 张晓艳[2] 

机构地区：[1]北京大学中日友好临床医学院,100029 [2]中日友好医院皮肤病与性病科

出　　处：《国际皮肤性病学杂志》2017年第5期285-288,共4页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81573048）

摘　　要：银屑病和慢性炎症性肠病这两种炎症性疾病在发病机制方面具有一定的共性，皮肤和肠道同时代表身体内外两侧的屏障和连接。二者均有多基因遗传背景且在炎症反应过程中存在重叠，在流行病学和治疗上的联系也进一步证实了二者发病机制的相关性。全基因组关联研究的发展已证实银屑病和慢性炎症性肠病的遗传相关性。Th17、调节性T细胞和细胞因子如白细胞介素12、23、17、肿瘤坏死因子α和干扰素γ也被证实在银屑病和炎症性肠病的发病过程中起作用。流行病学研究发现，二者常合并发生并且此类患者银屑病初发时间更早、病情更重、病程更长，同时合并症更多，二者合并是否影响疾病治疗及预后尚缺乏大样本流行病学研究。目前银屑病合并慢性炎症性肠病的治疗仍有局限，多种新型生物制剂将为炎症性肠病合并银屑病的治疗提供新的选择。Psoriasis and chronic inflammatory bowel disease（IBD）are closely related inflammatory diseases, and the skin and bowel both represent the barrier and connection between the inside and outside of the body. Psoriasis and chronic IBD are both polygenically inherited, and show some overlaps in inflammatory reaction process. Their associations in epidemiology and therapeutics further support a correlation in pathogenesis between the two diseases. Several genetic correlations between psoriasis and chronic IBD have been proved by genome wide association studies （GWAS）. T-helper 17 （Thl7） cells, regulatory T （Treg） cells and cytokines, such as interleukin-12 （IL-12）, IL-23, IL-17, tumor necrosis factor- α （TNF-α） and interferon-γ/ （IFN-γ）, have been proved to play roles in the occurrence of psoriasis and chronic IBD. Epidemiological studies have found that the two diseases often occur simultaneously, and patients with the two diseases are usually characterized by early onset of psoriasis, severer disease condition, longer disease duration and more complications. However, whether their concurrence will affect the treatment and prognosis still needs large-scale epidemiological studies. At present, the treatment of psoriasis complicated by chronic IBD is still limited, but the emergence of a variety of novel biological agents will provide new strategies for the treatment.

关 键 词：银屑病 流行病学 遗传 治疗应用 炎症性肠病 

分 类 号：R574[医药卫生—消化系统] R758.63[医药卫生—内科学]