基础窦卵泡数预测体外授精超排卵周期卵巢低反应的Meta分析  

Meta-analysis of poor ovarian response to ovarian hyperstimulation during IVF cycles predicted with bAFC

作　　者：张晓莉[1] 张晓潇 郑丽萍[2] 孟婷 

机构地区：[1]武警总医院妇产科,北京100039 [2]武警总医院信息科,北京100039 [3]山东总队直属支队卫生队,济南250000

出　　处：《武警医学》2017年第8期784-788,共5页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨在体外授精(in-vitro fertilization,IVF)超排卵周期,基础窦卵泡数(basisantral follicle count,b AFC)预测卵巢低反应性的价值。方法收集国内外有关b AFC与IVF超排卵周期卵巢低反应的相关研究,符合纳入与排除标准的相关文献共11篇,涉及患者11425例,采用Rev Man5.2软件对纳入的文献进行meta分析。结果通过对纳入的11项研究进行meta分析显示,b AFC直接影响获卵数和促性腺激素(Gn)使用量(支),b AFC越多,获卵数越多,促性腺激素(Gn)使用量越少,差异有统计学意义。获卵数(SMD合并-0.87,95%CI:-1.22--0.52;Z=4.84,P<0.00001);促性腺激素(Gn)使用量(支)(SMD合并0.68,95%CI:0.21-1.15;Z=2.83,P=0.005)。结论 b AFC对IVF超排卵周期卵巢低反应性具有预测价值,可作为独立监测指标。Objective To conduct meta-analysis of b AFC prediction of poor ovarian response to ovarian hyperstimulation during IVF cycles. Methods According to inclusion and exclusion criteria,data on related studies of antral follicle count and poor ovarian response was collected via electronic databases. A total of eleven pieces of literature involving 11425 patients were included and metaanalysis was made with Rev Man5. 2 software. Results Eleven studies were included in the meta-analysis. The results showed that along with the increase of b AFC,the number of oocytes obtained became larger. b AFC had a direct effect on the number of oocytes retrieved and the amount of gonadotropin（ Gn） used. Conclusions Meta-analysis suggests that b AFC can serve both as a predictor of poor ovarian response to ovarian hyperstimulation during IVF cycles and as an independent indicator of surveillance.

关 键 词：基础窦卵泡数 卵巢低反应性 体外授精 META分析 

分 类 号：R711.6[医药卫生—妇产科学]