中西医结合治疗IgA肾病风湿内扰证临床观察  

Clinical Observation of Integrated Chinese and Western Medicine Therapy for IgA Nephropathy with Syndrome of Disturbance of Wind and Dampness

作　　者：张红[1] 沈元丽[2] 陈凯[2] 邵海英[2] 李杰一[2] 

机构地区：[1]郑州大学附属南阳市中心医院肾病风湿免疫科,河南南阳473400 [2]开封市第二人民医院肾病风湿科,河南开封475000

出　　处：《新中医》2017年第9期54-56,共3页New Chinese Medicine

摘　　要：目的:观察中西医结合治疗IgA肾病风湿内扰证患者的临床疗效。方法:选择152例IgA肾病风湿内扰证患者,随机分为观察组和对照组,每组76例,对照组单纯行西医治疗,观察组在对照组西医治疗的基础上加用祛风愈肾汤治疗。2组均以3周为1疗程,连续治疗4疗程。观察2组患者的临床疗效、肾功能指标的变化及不良反应发生情况。结果:经4疗程治疗后,观察组总有效率(90.79%)高于对照组(72.37%),差异有统计学意义(P<0.01)。2组24h尿蛋白定量、血肌酐及尿红细胞水平均低于治疗前(P<0.01);观察组24h尿蛋白定量、血肌酐及尿红细胞水平均低于对照组(P<0.05,P<0.01),血尿素氮水平与对照组比较,差异无统计学意义(P>0.05)。观察组不良反应发生率(9.21%)低于对照组(30.26%),差异有统计学意义(P<0.01)。结论:采用中西医结合治疗IgA肾病风湿内扰证患者可以提高临床疗效,改善肾功能,降低不良反应发生率。Objective： To observe the clinical effect of integrated Chinese and western medicine therapy for IgA nephropathy with syndrome of disturbance of wind and dampness. Methods： Selected 152 cases of patients with IgA nephropathy with syndrome of disturbance of wind and dampness, and divided them into the observation group and the control group randomly,76 cases in each group. The control group was only treated with western medicine, while the observation group was treated with western medicine combined with Qufeng Yushen tang. Both groups received treatment for three weeks as one course,four courses continuously. Observed the clinical effect, renal function indexes and adverse reaction in both groups. Results：After four courses, the total effective rate in the observation group（90.79%） was higher than that in the control group（72.37%）,the difference being significant（P〈0.01）. The 24 h urinary albumin excretion, serum creatinine and levels of urine erythrocyte in both groups were lower than those before treatment（P〈0.01）; the 24 h urinary albumin excretion, serum creatinine and levels of urine erythrocyte in the observation group were lower than those in the control group（P〈0.05, P〈0.01）. Compared the levels of blood urea nitrogen in the observation group with that in the control group, there was no significant difference（P〈0.05）. The incidence of adverse reaction in the observation group（9.21%） was lower than that in the control group（30.26%）（P〈0.01）. Conclusion： Integrated Chinese and western medicine therapy for IgA nephropathy with syndrome of disturbance of wind and dampness can enhance the clinical effect, improve renal function and reduce the incidence of adverse reaction.

关 键 词：IGA肾病 风湿内扰证 中西医结合疗法 祛风愈肾汤 肾功能 

分 类 号：R692.31[医药卫生—泌尿科学]