复方丹参注射液联合盐酸拉贝洛尔片治疗早发型重度子痫前期临床观察  

Clinical Observation of Compound Danshen Injection Combined with Labetalol Hydrochloride Tablets in Treating Early Onset Severe Preeclampsia

作　　者：王玉双[1] 文亚南[1] 司亚茹[1] 薛汝萍 夏艳红[1] 王凤华[1] 王瑾[1] 

机构地区：[1]唐山市中医医院,河北唐山063000

出　　处：《新中医》2017年第9期88-90,共3页New Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2015239)

摘　　要：目的:观察复方丹参注射液联合盐酸拉贝洛尔片治疗早发型重度子痫前期的临床疗效。方法:选取40例早发型重度子痫前期患者,随机分为观察组和对照组各20例。观察组予复方丹参注射液合盐酸拉贝洛尔片治疗,对照组予25%硫酸镁注射液合盐酸拉贝洛尔片治疗。观察2组治疗前后平均动脉压(MAP)、24h尿蛋白定量(UP)、24h尿量(UV)、红细胞压积(HCT)、血小板计数(BPC)、D-二聚体(DD)、纤维蛋白原(Fib)及胎儿脐动脉收缩压与舒张压的比值(S/D)、羊水指数(AFI)的变化。结果:治疗后,2组MAP及UP均较治疗前降低(P<0.05),UV均较治疗前增加(P<0.05);观察组的UP低于对照组(P<0.05),UV高于对照组(P<0.05)。治疗后,2组BPC、DD、Fib水平均较治疗前降低(P<0.05),观察组BPC、DD、Fib水平比对照组下降更显著(P<0.05)。治疗后,2组S/D均减小(P<0.05),AFI均升高(P<0.05);观察组的S/D小于对照组(P<0.05),AFI高于对照组(P<0.05)。观察组活产数多于对照组,重度窒息和死产数低于对照组,差异均有统计学意义(P<0.05)。结论:复方丹参注射液联合盐酸拉贝洛尔片治疗早发型重度子痫前期,有利于改善患者的肾功能和胎盘供血,缓解血液高凝状态,降低血压,治疗效果优于硫酸镁注射液。Objective： To observe the clinical effect of compound Danshen injection combined with Labetalol hydrochloride tablets in treating early onset severe preeclampsia. Methods： Divided 40 cases of patients with early onset severe preeclampsia into the observation group and the control group randomly, 20 cases in each group. The observation group was treated with compound Danshen injection combined with Labetalol hydrochloride tablets, while the control group was treated with Labetalol hydrochloride tablet combined with 25% Magnesium sulfate injection. Observed change of mean arterial pressure（MAP）, 24 hours urinary protein excretion（UP）, urine volume（UV）, Hematocrit（HCT）, platelet count（BPC）, D-dimer（DD）, fibrinogen（Fib）and systolic/diastolic（S/D）ratio in the umbilical artery, amniotic fluid index（AFI）. Results： After treatment, levels of MAP and 24 h UP in both groups were lower than those before treatment（P〈0.05）, 24 h UV was increased when compared with that before treatment, differences being significant（P〈0.05）. Levels of 24 h UP of the observation group were lower than those of the control group（P〈0.05）, while 24 h UV was higher than that of the control group（P〈0.05）. After treatment, levels of BPC,DD and Fib in both groups were decreased when compared with those before treatment, and the decrease in the observation group was more significant（P〈0.05）. After treatment, S/D in both groups was decreased（P〈0.05）, AFI in both groups were increased（P〈0.05）; S/D of the observation group was lower than that of the control group（P〈0.05）, and AFI was higher than that of the control group（P〈0.05）. Amount of live births of the observation group was more than that of the control group, and the amount of severe asphyxia and stillbirth was lower than that of the control group, differences all being significant（P〈0.05）.Conclusion： Compound Danshen injection combined with Labetalol hydrochloride tablet can improve renal functi

关 键 词：早发型重度子痫前期 复发丹参注射液 盐酸拉贝洛尔片 硫酸镁注射液 平均动脉压(MAP) 肾功能 

分 类 号：R714.245[医药卫生—妇产科学]