桑菊饮合止咳散加减联合阿奇霉素治疗小儿肺炎支原体感染临床观察  

Clinical Observation of Modified Sangju Yin and Zhike San Combined with Azithromycin in Treating Mycoplasma Pneumoniae Infection in Children

作　　者：赵西斌[1] 李燕宁[2] 

机构地区：[1]嘉兴市中医医院儿科,浙江嘉兴314001 [2]山东省中医院儿科,山东济南250000

出　　处：《新中医》2017年第9期107-109,共3页New Chinese Medicine

摘　　要：目的:观察桑菊饮合止咳散加减联合阿奇霉素注射液治疗小儿肺炎支原体感染的临床疗效。方法:选取80例肺炎支原体感染患儿,根据随机数字表法分为治疗组和对照组各40例。治疗组给予桑菊饮合止咳散加减联合阿奇霉素注射液治疗,对照组单纯使用阿奇霉素注射液治疗。观察2组临床疗效及免疫功能指标的变化,统计患者的症状消失时间及复发率。结果:治疗组总有效率92.5%,对照组总有效率72.5%,2组比较,差异有统计学意义(P<0.05)。治疗组肺部啰音、发热、咳嗽咯痰消失时间及病灶吸收时间均短于对照组(P<0.05)。治疗后,2组CD3、CD4水平均较治疗前升高,差异均有统计学意义(P<0.05);治疗组2项指标水平均较对照组升高更明显,差异均有统计学意义(P<0.05)。随访3月,治疗组复发1例,复发率4.8%(1/21);对照组复发3例,复发率21.4%(3/14)。2组复发率比较,差异无统计学意义(P>0.05)。结论:桑菊饮合止咳散加减联合阿奇霉素治疗小儿肺炎支原体感染,能显著缓解患儿肺部啰音、发热、咳嗽咯痰等症状,增强免疫功能。Objective： To observe the clinical effect of modified Sangju yin and Zhike san combined with azithromycin in treating mycoplasma pneumoniae infection in children. Methods： Selected 80 cases of children with mycoplasma pneumoniae infection, and divided them into the treatment group and the control group according to random table method, 40 cases in each group. The treatment group was treated with modified Sangju yin and Zhike san combined with azithromycin, while the control group was treated with azithromycin injection only. Observed clinical effect and change of immune function indexes, and recorded time of symptom disappeared and recurrence rate. Results： The total clinical effective rate was 92.5% in the treatment group and 72.5% in the control group, the difference being significant（P〈0.05）. Time of pulmonary rales, fever, cough and expectoration disappeared and absorption time of lesions of the treatment group were all shorter than those of the control group（P〈0.05）. After treatment, CD3 levels and CD4 levels of the two groups were higher than those before treatment（P〈0.05）.Improvement of levels of the two indexes of the treatment group was more obvious, the difference being significant（P〈0.05）.Follow-up for three months, there was one case of recurrence in the treatment group with the recurrence rate being 4.8%,while there was three cases of recurrence in the control group with the recurrence rate being 21.4%. Compared recurrence rate of the two groups, there was no significant difference（P〈0.05）. Conclusion： Modified Sangju yin and Zhike san combined with azithromycin can effectively relieve pulmonary rales, fever, cough and expectoration, and improve immune function in treating mycoplasma pneumoniae infection in children.

关 键 词：小儿肺炎 支原体感染 风热犯肺证 桑菊饮 止咳散 阿奇霉素注射液 免疫功能 

分 类 号：R725.6[医药卫生—儿科] R518.9[医药卫生—临床医学]