基于数据挖掘对中医古籍眼科点眼方剂用药规律分析  

Medicine Law Analysis on Ophthalmological Eye-drop Prescription in Ancient Books of Chinese Medicine Based on Data Mining

作　　者：陈兹满[1] 张伟键[1] 庞龙[1] 欧扬[1] 李振萍[1] 张梅芳[1] 

机构地区：[1]广东省中医院眼科,广东广州510120

出　　处：《新中医》2017年第9期142-146,共5页New Chinese Medicine

基　　金：2014年张梅芳全国名老中医药专家传承工作室项目(201420)

摘　　要：目的:基于数据挖掘技术分析中医古籍外治点眼方剂的组方规律。方法:从9部眼科专著及4部综合类医学著作中筛选出外治点眼方进行整理,并建立眼科外治点眼方剂基本数据库,借助计算机软软件,通过频数分析、穷举算法、关联规则等,对古代点眼方剂配伍特点和用药规律进行分析研究。结果:筛选出主治外障眼病的点眼方910个,包含中药472味,对使用频次累积百分比前80%的60味药物进行分析,主要以开窍发散、清热泻火、收湿敛疮、退翳明目、杀虫止痒药物为主;使用Bibxcel进行文本知识单元关联分析获得频次≥30的药对组合21对;基于Matlab穷举运算得到具体3、4、5味药物组合中前20位组合,并以此取得含高频药组的核心方药7首。结论:中医古籍收载的外障眼病点眼方侧重以清热泻火配伍收湿敛疮、拔毒生肌类药品,并重视引经药及介类明目之品的使用;核心药组多以黄连炉甘石散(黄连、炉甘石、冰片)为基础加减化裁而成。Objective： To analyze the composition principles of eye-drop prescription for external treatment based on the ancient books of Chinese medicine. Methods： Screen out the eye-drop prescription for external treatment from 9 ophthalmological monographs and 4 comprehensive medical books; build the basic database for eye-drop prescription of ophthalmological external treatment; study the compatible characteristics and medicine law of the ancient eye-drop prescription with the help of computer software by frequency analysis, exhaustive algorithm and association rules. Results：Nine hundreds and ten eye-drop prescriptions for external oculopathy were screened out, including 472 kinds of herbal medicine. Analyzed 60 kinds, which was the first 80% of the cumulative percentage of usage frequency, found that most of them were for resuscitating and diverging, clearing heat and draining fire, removing nebula to improve vision, destroying parasites and relieving itching. Applied Bibxcel to unit correlation of text knowledge, and 21 pairs of medicine combination whose frequency≥30 were obtained through analysis. Based on the exhaustive algorithm of Matlab, first 20 combinations of the specific 3, 4 and 5 kinds of medicine combination were obtained and according to which 7 core prescriptions of the high-frequency combinations were also obtained. Conclusions： The eye-drop prescriptions for external oculopathy recorded in ancient books of Chinese medicine focus on the medicine of clearing heat and draining fire combined with astringing dampness and furuncle, removing toxic and regenerating tissue, as well as emphasizing the use of channel envoy, testacean and medicine of vision-improving. Core medicine combinations are mainly modified on the basis of Huanglian Luganshi San（Huanglian, Luganshi, Bingpian）.

关 键 词：眼科 中医古籍 外治 点眼方剂 数据挖掘 

分 类 号：R276.7[医药卫生—中医五官科学]