三种方案治疗小儿重症肺炎的临床效果及安全性比较  

Comparison of the Clinical Effect and Safety of Three Dosage Regimens in the Treatment of Children with Severe Pneumonia

作　　者：赵文静[1] 艾婷[2] 党清华 孙艳[1] 高小倩[1] 高颂轶[1] 

机构地区：[1]西安市中心医院儿科,陕西西安710003 [2]西安交通大学第一附属医院儿科,陕西西安710003

出　　处：《现代生物医学进展》2017年第26期5141-5144,共4页Progress in Modern Biomedicine

摘　　要：目的:比较三种方案治疗小儿重症肺炎的临床效果及安全性。方法:选取我院于2012年1月~2016年1月收治的120例重症肺炎患儿,按照不同的治疗方法随机分为观察组1(多巴胺联合多巴酚丁胺)42例,观察组2(多巴胺联合酚妥拉明)40例及对照组38例。比较三组患者临床疗效及炎症因子水平的变化。结果:观察组1的总有效率为90.48%,观察组2的总有效率为87.5%,均显著高于对照组的总有效率(63.16%)。观察组(1、2)的肺啰音消失时间、咳嗽症状消失时间、呼吸困难改善时间、退热时间以及住院天数均显著短于对照组(p<0.05)。治疗后,三组患者的血清白介素6(IL-6)、白介素8(IL-8)、C反应蛋白(CRP)以及肿瘤坏死因子(TNF-α)的水平与治疗前相比均显著降低,差异均具有统计学意义(p<0.05),且观察组患者以上指标的水平均显著低于对照组(p<0.05)。结论:多巴胺联合多巴酚丁胺和多巴胺联合酚妥拉明治疗小儿重症肺炎的疗效和安全性相当,二者均明显优于常规治疗。Objective： To compare the clinical effect and safety of three different regimens treating children with severe pneumonia. Methods： 120 cases treated in our hospital from January, 2012 to January, 2016 were randomly divided into the observation group 1 （dopamine combined with dobutamine, 42 cases）, observation group 2 （dopamine combined with phentolamine, 40 cases）, control group （38 cases）. The clinical effect and levels of inflammatory cytokine were compared between the three groups. Results： The total effective rate in the observation group 1 was 90.48% and that of observation group 2 was 87.5%, which were significantly higher than that of the control group （63.16%）. The disappearance time of pulmonary rales, cough, dyspnea, pyretolysis and length of stay in the observation group （both 1, 2） were significantly shorter than those of the control group （p 〈 0.05）. After therapy, the level of serum IL-6, IL-8, CRP and TNF-α in all the three groups were obviously decreased compared with those of before therapy （p〈0.05）, and those of the observation group were significantly lower than the control group （p〈0.05）. Conclusion： Dopamine combined with dobutamine as well as dopamine combined with phentolamine were both effective methods in treating children with severe pneumonia, which were significantly better than conventional therapy.

关 键 词：小儿重症肺炎 多巴胺 多巴酚丁胺 酚妥拉明 炎性因子 

分 类 号：R563.1[医药卫生—呼吸系统]