二甲双胍联合津力达颗粒治疗妊娠期糖尿病的临床效果及对患者血清VEGF、APN、Hcy水平的影响  

Curative Efficacy of Metformin Combined with Jinlida Granules in Treatment of Gestational Diabetes Mellitus and Its Effects on Serum VEGF,APN and Hcy Levels

作　　者：赵骏达 武建利[2] 李燕[1] 王娟[1] 殷艳[2] 

机构地区：[1]新疆医科大学第一附属医院妇科中心,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院母胎医学中心,新疆乌鲁木齐830054

出　　处：《现代生物医学进展》2017年第25期4869-4872,共4页Progress in Modern Biomedicine

基　　金：新疆自治区自然科学基金项目(09KH1483)

摘　　要：目的:探讨二甲双胍联合津力达颗粒治疗妊娠期糖尿病的临床效果及对患者血清血管内皮生长因子(VEGF)、脂联素(APN)、同型半胱氨酸(Hcy)水平的影响。方法:选择2014年7月至2016年7月我院接诊的94例妊娠期糖尿病患者并通过随机数表法分为观察组(n=47)和对照组(n=47)。对照组使用二甲双胍治疗,观察组在对照组的基础上联合津力达颗粒治疗,均治疗至胎儿娩出。比较两组治疗前后血糖、血脂及血清VEGF、APN和Hcy水平的变化及产妇并发症和新生儿不良结局的发生情况。结果:与治疗前比较,两组治疗后血糖、血脂指标均显著改善(P<0.05),观察组空腹血糖(FBG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显低于对照组,血清高密度脂蛋白胆固醇(HDL-C)水平明显高于对照组(P<0.05)。两组治疗后血清VEGF、APN、Hcy水平较治疗前均显著改善(P<0.05),且观察组血清VEGF、Hcy均明显低于对照组,血清APN水平明显高于对照组(P<0.05)。观察组妊娠期高血压、羊水过多、剖宫产、早产、巨大儿、新生儿黄疸、新生儿呼吸窘迫的发生率均明显低于对照组(P<0.05)。结论:二甲双胍联合津力达颗粒治疗妊娠期糖尿病的临床效果显著,可有效控制血糖、血脂水平,降低不良母婴结局的发生率,可能与其有效调节血清VEGF、APN、Hcy水平有关。Objective：To study the curative efficacy of metformin combined with Jinlida granules in the treatment of gestational diabetes mellitus and its effects on the serum vascular endothelial growth factor （VEGF）,adiponectin （APN） and homocysteine（Hcy） levels.Methods：94 patients of gestational diabetes mellitus who were treated from July 2014 to July 2016 in our hospital were selected.According to random number table,those patients were divided into the observation group （n=47） and the control group （n=47）.On the basis of routine treatment,such as control diet,reasonable exercise and healthy diet,etc,the control group was treated with metformin,while the observation group was combined with Jinlida granules on the basis of the control group.The changes of blood glucose,blood lipid and serum VEGF,APN and Hcy before and after treatment were compared between the two groups,the incidence of maternal complications and neonatal adverse outcomes were compared.Results：Compared with before treatment,the blood glucose,blood lipid of both groups after treatment were significantly improved （P 〈0.05）,the fasting plasma glucose （FBG）,postprandial 2h blood glucose （2hPG）,glycosylated hemoglobin （HbAlc）,total cholesterol （TC）,triacylglycerol （TG）,low density lipoprotein cholesterol（LDL-C） of observation group were significantly lower than those of the control group,the serum high density lipoprotein cholesterol （HDL-C） level was significantly higher than that of the control group（P〈0.05）;after treatment,the serum VEGF,APN and Hcy levels were significantly improved than those before treatment in both groups （P〈0.05）,and the serum VEGF,and Hcy levels of observation group were lower than those of the control group,the serum APN level was higher than that of the control group （P 〈 0.05）;the incidence of gestational hypertension,hydramnios,cesarean section and premature delivery of observation group was significantly lower than that of the control group （P 〈0.0

关 键 词：妊娠期糖尿病 二甲双胍 津力达颗粒 血管内皮生长因子 脂联素 同型半胱氨酸 

分 类 号：R587.1[医药卫生—内分泌] R714.256[医药卫生—内科学]