血府逐瘀胶囊对大鼠急性心肌缺血及心肌线粒体超微结构的影响  

Effects of Xuefu Zhuyu Capsule on acute Myocardial Ischemia and Ultrastructure of Myocardial Mitochondria in Rats

作　　者：王梓[1] 杨欣莹[2] 吕楠[1] 赵亮[2] 王宏[1] 王蕾[1] 

机构地区：[1]天津市医药科学研究所,天津300020 [2]天津宏仁堂药业有限公司,天津300000

出　　处：《中国中医基础医学杂志》2017年第8期1067-1070,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：天津市"杀手锏"产品研发项目(14ZXSSSY01330)

摘　　要：目的:观察血府逐瘀胶囊对大鼠急性心肌缺血及心肌线粒体超微结构的影响。方法:采用冠状动脉左前降支结扎制备大鼠急性心梗模型,给药5 d,通过死亡率、心电图、心脏超声心动、血浆cTn-T、心肌梗死质量、心肌间质及血管周围胶原Ⅰ、Ⅲ型胶原分布,电镜观察心肌线粒体超微结构阐明血府逐瘀胶囊对急性心梗的治疗作用及机制。结果:血府逐瘀各剂量组术后即刻死亡率均较模型组降低,cTn-T、LDH、CK降低明显,高、低剂量组可明显降低ST段并改善心功能。各剂量组心肌胶原表达显著降低,对心肌线粒体结构有明显改善作用。结论:血府逐瘀胶囊对大鼠急性心肌梗死有明确的治疗作用,可降低死亡率,降低血浆cTnT、LDH、CK,改善心电图ST段,增加射血分数,减小左室内径,降低心肌胶原表达,改善心肌线粒体超微结构。Objective： To observe the effect of Xuefu Zhuyu capsule on rats‘ acute myocardial ischemia and myocardial mitochondria＇s ultra structure. Methods： The acute myocardial infarction model was made by the ligation of left anterior descending coronary artery in rats. Administration of 5d. Mortality,electrocardiogram,cardiac echocardiography,cTn-T,myocardial infarction weight,myocardial interstitial and perivascular collagen type Ⅰ、Ⅲ collagen distribution,myocardial mitochondrial ultrastructural,clarify the Xuefu Zhuyu Capsule on the acute myocardial infarction treatment effect and mechanism. Results： Mortality,cTn-T,LDH,CK,ECG ST reduced. Myocardial collagen expression was significantly reduced,and the structure of myocardial mitochondria was significantly improved. Conclusion： Xuefu Zhuyu capsule has a definite therapeutic effect on the acute myocardial infarction in rats,which can reduce the mortality rate,reduce plasma cTn-T,LDH,CK,improve the ECG ST segment,increase ejection fraction,decreased left ventricular diameter,reducing myocardial collagen expression,improve myocardial mitochondrial ultra structure.

关 键 词：血府逐瘀胶囊 急性心肌缺血 线粒体超微结构 透射电镜 

分 类 号：R542.2[医药卫生—心血管疾病]