双水相体系选择性萃取分离对氯扁桃酸对映体  

Selective separation of 4-chloromandelic acid enantiomers by aqueous two phase extraction

作　　者：陆瑞晨 彭阳峰[1] 赵红亮[1] 童天中[1] 

机构地区：[1]华东理工大学化工学院,上海200237

出　　处：《化学工程》2017年第9期18-23,共6页Chemical Engineering(China)

摘　　要：研究了对氯扁桃酸(4-ClMA)对映体在含有羟丙基-β-环糊精(HP-β-CD)的聚乙二醇(PEG)/硫酸铵[(NH_4)_2SO_4]双水相体系中的萃取分配行为。考察了pH、PEG相对分子质量、PEG质量分数、(NH_4)_2SO_4质量分数、HP-β-CD浓度、4-ClMA浓度以及萃取温度对拆分效果的影响。实验结果表明:双水相萃取拆分具有很好的手性分离能力,HP-β-CD对(R)-4-ClMA的识别能力大于对(S)-4-ClMA的识别能力;当pH=6.5,PEG2000的质量分数为20%,(NH_4)_2SO_4的质量分数为20%,HP-β-CD浓度为1 mmol/L,4-ClMA浓度为0.13 mmol/L,萃取温度为25℃时,分离因子α达到1.61,性能因数PfR达到0.065。The distribution behavior of 4-chloromandelic acid （4-ClMA） enantiomers was studied in aqueous two phase system consisted of polyethylene glycol （PEG）/ammonium sulfate [ （ NH4 ）2SO4 ] with hydroxypropyl-β-cyclodextrin （HP43-CD）. The influence of pH, relative molecular mass of PEG, mass fraction of PEG, mass fraction of （NH4 ）2 SO4, concentration of HP-β-CD, concentration of 4-ClMA and extractive temperature on enantiomeric separation were investigated. The results show that HP-β-CD is inclined to recognize （R）-4-ClMA. Under the condition of pH of 6.5, PEG2000 mass fraction of 20% , （ NH4 ）2SO4 mass fraction of 20% , HP-β-CD concentration of l mmol/L, 4-ClMA concentration of 0.13mmol/L and extractive temperature of 25 ℃, the highest enantioselective factor α of 1.61 and performance factor PfR of 0. 065 are obtained.

关 键 词：对氯扁桃酸 羟丙基-Β-环糊精 聚乙二醇 硫酸铵 双水相体系 萃取拆分 

分 类 号：TQ028.32[化学工程]