血糖水平对脑^(18)F-FDG PET/CT显像影响研究  

Effects of Blood Glucose Levels on Brain ^(18)-FDG PET/CT Imaging

作　　者：王治国[1] 战莹[1] 武晓丹[1] 陆国秀[1] 吴锐先[1] 张宗鹏[1] 张国旭[1] 

机构地区：[1]沈阳军区总医院核医学科,辽宁沈阳110016

出　　处：《四川医学》2017年第9期1004-1006,共3页Sichuan Medical Journal

基　　金：辽宁省自然科学基金(编号:20140220066);辽宁省自然科学基金(编号:20170540927)

摘　　要：目的研究血糖浓度对脑PET/CT扫描中摄取^(18)-FDG的影响。方法回顾性分析2014年1月至2015年12月在我院行全身及头部PET/CT显像患者70例。所有患者在扫描前进行血糖检测,根据血糖浓度分为正常对照组、血糖稍高组和高血糖组,采用视觉分析和半定量分析的方法分析PET图像,以小脑皮质作为参考区域计算其最大化标准摄取值。结果正常对照组、血糖稍高组和高血糖组血糖水平逐渐升高,差异有统计学意义(F=200.369,P<0.05);三组相应小脑皮质SUVmax值逐渐降低,差异有统计学意义(F=14.207,P<0.05);组内两两比较高血糖组与正常对照组和血糖稍高组差异有统计学意义(P<0.05),而血糖稍高组与正常对照组相比血糖水平差异无统计学意义(P>0.05)。脑^(18)FDG摄取与血浆血糖水平呈负相关。结论高血糖水平干扰了脑组织^(18)-FDG的摄取,对PET/CT显像产生了一定影响,因此在PET/CT检查前需将血糖控制在合理范围内。Objective To investigate the effect of blood glucose concentration on ^18F-FDG uptaking in brain PET/CT scans. Methods 70 patients who underwent whole-body and head PET/CT imaging in our hospital during January 2014 to December 2015 were retrospectively analyzed. Blood glucose of all patients was determined before scanning, and patients were divided into control group, slightly high blood glucose group and high blood glucose group. Visual analysis and semi quantitative analysis were adopted to analyze PET images and maximum standard uptake values were calculated according to cerebellar cortex as reference area. Results Blood glucose gradually increased following the sequence of control group, slightly high blood glucose group and high blood glucose group, the difference being statistically significant （ F = 200. 369, P 〈 0. 05 ） and in the meantime, SUVmax of cerebellar cortex gradually decreased ,the difference being statistically significant （F = 14. 207, P 〈 0. 05 ）. Comparing high blood glucose group with control group or slightly high blood glucose group, the difference was statistically significant （ P 〈 0. 05 ）, but comparing slightly high blood glucose group with control group, the difference was not statistically significant （P 〉 0. 05 ）. The brain uptake of ^18F-FDG was negatively correlated to blood glucose concentration. Conclusion High blood glucose interferes with brain uptake of ISF-FDG and influences PET/CT imaging, so blood glucose concentration should be controlled within a reasonable range before PET/CT examination.

关 键 词：血糖水平 脑显像 PET/CT ^18F-FDG 

分 类 号：R817.4[医药卫生—影像医学与核医学]