血清鸢尾素与2型糖尿病颈动脉粥样硬化的相关研究  

Correlation between serum irisin and carotid atherosclerosis in patients with type 2 diabetes mellitus

作　　者：李白洁[1] 范志宏[1] 丁明辉[1] 武少华[1] 李宁[1] 常小女[1] 马豆豆 

机构地区：[1]山西医科大学第二医院内分泌科,太原030001

出　　处：《中华糖尿病杂志》2017年第8期499-503,共5页CHINESE JOURNAL OF DIABETES MELLITUS

摘　　要：目的 探讨血清鸢尾素（irisin）与2型糖尿病（T2DM）颈动脉粥样硬化（CAS）的关系.方法 2014年6月至2015年12月,选取T2DM伴CAS患者30例,同时匹配30例T2DM不伴CAS患者,同期选择性别、年龄相匹配的健康体检者30名作为正常对照（NC）组.检测比较3组空腹血糖（FPG）、血脂、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）;酶联免疫吸附实验（ELISA）法测定血清鸢尾素水平.采用单因素方差分析、非参数检验、Spearman相关分析及Logistic回归分析进行统计学分析.结果 T2DM伴CAS组及不伴CAS组血清鸢尾素水平均显著低于NC组[分别为3.3（2.7,3.7）、4.0（3.7,4.3）、4.5（3.7,5.3） mg/L,Z=-3.150,-2.197,均P＜0.05];与不伴CAS组相比,T2DM伴CAS组血清鸢尾素水平显著降低（Z=-2.263,P＜0.05）.T2DM患者血清鸢尾素与稳态模型胰岛素抵抗指数、病程呈负相关（r=-0.312、-0.321,均P＜0.05）,与高密度脂蛋白胆固醇、舒张压呈正相关（r=0.321、0.285,均P＜0.05）.鸢尾素、高密度脂蛋白胆固醇是T2DM并发CAS的独立保护因素（B=-1.225、-4.332,均P＜0.05）.结论 鸢尾素可能与T2DM的发生、发展相关;鸢尾素水平降低,可能是T2DM患者大血管并发症发生、发展的原因之一.Objective To investigate the relationship between serum irisin and carotid atherosclerosis （CAS） in type 2 diabetes.Methods A total of 30 patients with type 2 diabetes （T2DM）complicated with CAS and another 30 gender-,age-matched T2DM patients without CAS were enrolled from June 2014 to December 2015;over the same period,30 gender-,age-matched healthy participants were included as the normal control （NC）.Fasting plasma glucose,blood lipid,glycosylated hemoglobin A1c,fasting insulin were measured;serum irisin level was determined by enzyme-linked immunosorbent assay.Analysis of covariance,nonparametric test,Spearman correlation analysis and Logistic regression analysis were used for data analysis.Results The serum irisin levels decreased significantly in T2DM with CAS and without CAS groups when compared with that in NC group 3.3（2.7,3.7）,4.0（3.7,4.3）,4.5（3.7,5.3） mg/L,respectively,Z=-3.150,-2.197,both P〈0.05）,and it was obviously lower in the CAS group than that in the T2DM without CAS group （Z=-2.263,P〈0.05）.The irisin level was negatively correlated with homeostasis model assessment of insulin resistance,duration of diabetes （r=-0.312,-0.321,both P〈0.05）,and was positively correlated with high density lipoprotein-cholesterol （HDL-C）,diastolic blood pressure （r=0.321,0.285,both P〈0.05）.Irisin and HDL-C were the independent protective factors for CAS （B=-1.225,-4.332,both P〈0.05）.Conclusion Irisin may be associated with the occurrence and development of T2DM;depressed serum irisin level may be one of the causes of occurrence and development of macroangiopathy in patients with T2DM.

关 键 词：糖尿病 2型 鸢尾素 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]