O型血孕妇产前IgG抗A（B）抗体效价与新生儿溶血病的相关性分析  

Correlation between prenatal immunoglobulin antibody titer and neonatal hemolytic disease in pregnant women with type O blood

作　　者：马菊芬[1] 张书芬[1] 张燕 

机构地区：[1]长治医学院附属和济医院输血科,山西长治046000

出　　处：《中国实用医刊》2017年第17期103-104,共2页Chinese Journal of Practical Medicine

摘　　要：目的 探讨O型血孕妇产前IgG抗A（B）抗体效价与新生儿溶血病（HDN）的相关性。 方法 收集984例夫妇血型不合的O型血孕妇临床资料进行回顾性分析，其中621例孕妇行IgG抗A（B）抗体效价检测，并对IgG抗A（B）抗体效价异常者行药物治疗；363例O型血孕妇未接受IgG抗A（B）抗体效价检测。分析产前IgG抗体效价与HDN发病的相关性。 结果 HDN的发病率与抗体效价呈正相关，随着抗体效价的升高，HDN的发病率升高（χ2＝18.07，P＝0.000）；检测组治疗后孕妇HDN发病率为3.54%（22/621），低于对照组的9.37%（34/363），χ2＝12.51，P＝0.002。 结论 HDN的发病率与IgG抗A（B）抗体效价呈正相关，开展IgG抗A（B）抗体效价检测并积极治疗，可降低HDN的发病率。Objective To investigate the correlation between prenatal IgG anti-A （B） antibody titer and neonatal hemolytic disease （HDN） in pregnant women with type O blood. Methods The clinical data of 984 couples with blood type incompatibility were collected and analyzed retrospectively. Among them, 621 pregnant women were tested for anti-A （B） antibody titer, and the IgG anti A （B） antibody fiter abnormality was treated by drug treatment; 363 cases of type O blood pregnant women did not receive IgG anti A （B） anti- body titer detection. The correlation between prenatal IgG antibody titer and the incidence of HDN was ana- lyzed. Results The incidence of HDN was positively correlated with the antibody titer, and the incidence of HDN was significantly increased with the increase of antibody titer （χ2 = 18. 07, P =0. 000）. The incidence of HDN group pregnant women was 3. 54% （22/621）, which was lower than 9. 37% （34/363） in control group （χ2 =12. 51, P =0.002）. Condusiorts The incidence of HDN is positively correlated with the titer of anti- A （B） antibody. Active therapy can reduce the incidence of HDN.

关 键 词：ABO血型 抗体效价 新生儿溶血病 

分 类 号：R446.6[医药卫生—诊断学] R722.18[医药卫生—临床医学]