抗肿瘤药玫瑰树碱及其衍生物的合成和药理研究进展  

Recent progress in synthesis and pharmacological effects of ellipticine and its derivatives

作　　者：林菁菁 杨亚军[1] 沈珑瑛[1] 潘显道[1] LIN Jing-jing YANG Ya-jun SHEN Long-ying PAN Xian-dao(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beo＇ing 100050, China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《药学学报》2017年第9期1387-1396,共10页Acta Pharmaceutica Sinica

摘　　要：玫瑰树碱(ellipticine)是一种来源于天然产物的细胞毒生物碱,具有抗肿瘤作用和抗艾滋病毒活性。自1959年首次被分离后,众多合成化学家设计并完成了玫瑰树碱的全合成路线。本文根据起始原料的不同对玫瑰树碱及衍生物的合成方法进行了综述,同时探讨了该类化合物的抗肿瘤活性作用机制,还对玫瑰树碱的抗肿瘤的构效关系进行了总结。Ellipticine is an alkaloid isolated from natural product with cytotoxicity, which has antitumor and anti-aids activity. Since it was first identified in 1959, a great deal of effort has been devoted to the development of various approaches for synthesis of ellipticine. This review provides a summary for synthesis approaches of ellipticine from different starting materials. The antitumor mechanism and structure-activity relationship are also discussed.

关 键 词：玫瑰树碱 合成 衍生物 抗肿瘤活性 作用机制 构效关系 

分 类 号：R916[医药卫生—药学]